High expression of NFX1‐123 in HPV positive head and neck squamous cell carcinomas

Background High‐risk human papillomaviruses (HR HPV) cause nearly all cervical cancers and, in the United States, the majority of head and neck cancers (HNSCCs). NFX1‐123 is overexpressed in cervical cancers, and NFX1‐123 partners with the HR HPV type 16 E6 oncoprotein to affect multiple growth, dif...

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Bibliographic Details
Published in:Head & neck 2022-01, Vol.44 (1), p.177-188
Main Authors: Chintala, Sreenivasulu, Quist, Kevin M., Gonzalez‐DeWhitt, Patricia A., Katzenellenbogen, Rachel A.
Format: Article
Language:English
Subjects:
Cancer
Cervical cancer
Genomes
Head & neck cancer
Head and neck carcinoma
Head and Neck Neoplasms - genetics
head and neck squamous cell carcinoma
Human papillomavirus
Humans
Immune response
NFX1‐123
Notch1
Notch1 protein
oropharyngeal cancer
Papillomaviridae
Papillomaviridae - genetics
Papillomavirus Infections - genetics
Repressor Proteins - genetics
Squamous cell carcinoma
Squamous Cell Carcinoma of Head and Neck - genetics
Throat cancer
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Summary:Background High‐risk human papillomaviruses (HR HPV) cause nearly all cervical cancers and, in the United States, the majority of head and neck cancers (HNSCCs). NFX1‐123 is overexpressed in cervical cancers, and NFX1‐123 partners with the HR HPV type 16 E6 oncoprotein to affect multiple growth, differentiation, and immune response genes. However, neither the expression of NFX1‐123 nor the levels of these genes have been investigated in HPV positive (HPV+) or negative (HPV−) HNSCCs. Methods The Cancer Genome Atlas Splicing Variants Database and HNSCC cell lines were used to quantify expression of NFX1‐123 and cellular genes increased in cervical cancers. Results NFX1‐123 was increased in HPV+ HNSCCs compared to HPV− HNSCCs. LCE1B, KRT16, SPRR2G, and FBN2 were highly expressed in HNSCCs compared to normal tissues. Notch1 and CCNB1IP1 had greater expression in HPV+ HNSCCs compared to HPV− HNSCCs. Conclusion NFX1‐123 and a subset of its known targets were increased in HPV+ HNSCCs.
ISSN:1043-3074
1097-0347
DOI:10.1002/hed.26906