Temporal Dynamics of Anti–Type 1 Interferon Autoantibodies in Patients With Coronavirus Disease 2019

Abstract Binding levels and neutralization activity of anti–type 1 interferon autoantibodies peaked during acute coronavirus disease 2019 and markedly decreased thereafter. Most patients maintained some ability to neutralize type 1 interferon into convalescence despite lower levels of binding immuno...

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Bibliographic Details
Published in:Clinical infectious diseases 2022-08, Vol.75 (1), p.e1192-e1194
Main Authors: Shaw, Elana R, Rosen, Lindsey B, Cheng, Aristine, Dobbs, Kerry, Delmonte, Ottavia M, Ferré, Elise M N, Schmitt, Monica M, Imberti, Luisa, Quaresima, Virginia, Lionakis, Michail S, Notarangelo, Luigi D, Holland, Steven M, Su, Helen C
Format: Article
Language:English
Subjects:
Autoantibodies
Brief Report
COVID-19
Humans
Immunoglobulin G
Interferon Type I
Interferon-alpha
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Summary:Abstract Binding levels and neutralization activity of anti–type 1 interferon autoantibodies peaked during acute coronavirus disease 2019 and markedly decreased thereafter. Most patients maintained some ability to neutralize type 1 interferon into convalescence despite lower levels of binding immunoglobulin G. Identifying these autoantibodies in healthy individuals before the development of critical viral disease may be challenging.
ISSN:1058-4838
1537-6591
DOI:10.1093/cid/ciab1002