Xanthones and anthraquinones from the soil fungus Penicillium sp. DWS10-P-6

Two new xanthones, oxisterigmatocystins J and K (1-2), and two new anthraquinones, versicolorins D and E (3-4), were isolated from solid cultures of the fungus sp. DWS10-P-6, together with twelve known compounds (5-16). Their structures, including their absolute configurations, were characterized on...

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Bibliographic Details
Published in:RSC advances 2021-01, Vol.11 (5), p.3162-3167
Main Authors: Wang, Ya-Jing, Ma, Nan, Liu, Chun-Yue, Feng, Yi-Xuan, Zhang, Feng-Xiang, Li, Chang, Pei, Yue-Hu
Format: Article
Language:English
Subjects:
Anthraquinones
Chemistry
Cytotoxicity
Fungi
NMR
Nuclear magnetic resonance
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Summary:Two new xanthones, oxisterigmatocystins J and K (1-2), and two new anthraquinones, versicolorins D and E (3-4), were isolated from solid cultures of the fungus sp. DWS10-P-6, together with twelve known compounds (5-16). Their structures, including their absolute configurations, were characterized on the basis of extensive 1D NMR, 2D NMR, MS and CD spectral data. The cytotoxic activities of compounds 1-12 against HL-60, MDA-MB-231 and PC-3 cells were also evaluated. Compounds 4 and 5 showed significant cytotoxic activity against the HL-60 cell line with IC values of 1.65 μM and 1.05 μM, respectively.
ISSN:2046-2069
2046-2069
DOI:10.1039/d0ra08141h