Transition metal-catalyzed synthesis of spirooxindoles

Spirooxindole is a principal bioactive agent and is observed in several natural products including alkaloids. They are broadly studied in the pharmaceutical field and have a significant role in the evolution of drugs such as anti-viral, anti-cancer, anti-microbial etc. In organic chemistry, an indis...

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Bibliographic Details
Published in:RSC advances 2021-02, Vol.11 (13), p.7146-7179
Main Authors: Saranya, P. V, Neetha, Mohan, Aneeja, Thaipparambil, Anilkumar, Gopinathan
Format: Article
Language:English
Subjects:
Antiinfectives and antibacterials
Catalysts
Chemical synthesis
Chemistry
Microorganisms
Natural products
Organic chemistry
Transition metals
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Summary:Spirooxindole is a principal bioactive agent and is observed in several natural products including alkaloids. They are broadly studied in the pharmaceutical field and have a significant role in the evolution of drugs such as anti-viral, anti-cancer, anti-microbial etc. In organic chemistry, an indispensable role is presented by transition metal catalysts. An effective synthetic perspective to spirooxindoles is the use of transition metals as the catalyst. This review discusses the synthesis of spirooxindoles catalyzed by transition metals and covers literature up to 2020. Spirooxindoles are used as anticancer-, antiviral-, antimicrobial agents etc. The use of transition metals as catalysts for the synthesis of spirooxindoles is advancing rapidly. Here, we focus on recent advances in transition metal-catalyzed synthesis of spirooxindoles.
ISSN:2046-2069
2046-2069
DOI:10.1039/d1ra00139f