Vicinal halo-trifluoromethylation of alkenes

Both trifluoromethyl and halide groups are widely found in medicinally and pharmaceutically important compounds and, moreover, organohalides are commonly used as versatile intermediates in synthetic organic chemistry. Due to their prevalence and easy accessibility, alkene halo-trifluoromethylation p...

Full description

Saved in:
Bibliographic Details
Published in:RSC advances 2021-04, Vol.11 (25), p.14941-14955
Main Authors: Kareem, Rzgar Tawfeeq, Azizi, Bayan, Asnaashariisfahani, Manzarbanou, Ebadi, Abdolghaffar, Vessally, Esmail
Format: Article
Language:English
Subjects:
Alkenes
Chemistry
Organic chemistry
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:Both trifluoromethyl and halide groups are widely found in medicinally and pharmaceutically important compounds and, moreover, organohalides are commonly used as versatile intermediates in synthetic organic chemistry. Due to their prevalence and easy accessibility, alkene halo-trifluoromethylation provides a convenient way to install these valuable functionalities in complex targets. In this review, we summarize recent advances and achievements in this fast-growing research field. For clarity, the reactions were classified according to the type of halogen atom. Both trifluoromethyl and halide groups are widely found in medicinally and pharmaceutically important compounds and, moreover, organohalides are commonly used as versatile intermediates in synthetic organic chemistry.
ISSN:2046-2069
2046-2069
DOI:10.1039/d0ra06872a