Virulent rough filaments of Listeria monocytogenes from clinical and food samples secreting wild-type levels of cell-free p60 protein

Atypical rough cell filaments of Listeria monocytogenes (designated FR variants), isolated from clinical and food samples, form long filaments up to 96 microm in length and demonstrated wild-type levels of adherence, invasion, and cytotoxicity to human epithelial HEp-2, Caco-2, and HeLa cells. Unlik...

Full description

Saved in:
Bibliographic Details
Published in:Journal of clinical microbiology 2000-07, Vol.38 (7), p.2643-2648
Main Authors: ROWAN, N. J, CANDLISH, A. A. G, BUBERT, A, ANDERSON, J. G, KRAMER, K, MCLAUCHLIN, J
Format: Article
Language:English
Subjects:
Bacterial Adhesion
Bacterial Proteins - metabolism
Bacteriology
Biological and medical sciences
Caco-2 Cells
Food Microbiology
Fundamental and applied biological sciences. Psychology
HeLa Cells
Humans
Listeria monocytogenes
Listeria monocytogenes - growth & development
Listeria monocytogenes - isolation & purification
Listeria monocytogenes - pathogenicity
Listeriosis - microbiology
Microbiology
Microscopy, Electron
p60 protein
Pathogenicity, virulence, toxins, bacteriocins, pyrogens, host-bacteria relations, miscellaneous strains
Virulence
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:Atypical rough cell filaments of Listeria monocytogenes (designated FR variants), isolated from clinical and food samples, form long filaments up to 96 microm in length and demonstrated wild-type levels of adherence, invasion, and cytotoxicity to human epithelial HEp-2, Caco-2, and HeLa cells. Unlike previously described avirulent rough mutants of L. monocytogenes that secrete diminished levels of the major extracellular protein p60 and that form long chains that consist of multiple cells of similar size (designated MCR variants), FR variants secreted wild-type or greater levels of p60. This study shows that virulent filamentous forms of L. monocytogenes occur in clinical and food environments and have atypical morphological characteristics compared to those of the wild-type form.
ISSN:0095-1137
1098-660X
DOI:10.1128/JCM.38.7.2643-2648.2000