The Complex Network between Inflammation and Colorectal Cancer: A Systematic Review of the Literature

colorectal cancer (CRC) has a multifactorial etiology which comprises microbiota, genetic predisposition, diet, environmental factors, and last but not least, a substantial contribution by inflammation. The aim of this study is to conduct a systematic review of the literature regarding the strong li...

Full description

Saved in:
Bibliographic Details
Published in:Cancers 2021-12, Vol.13 (24), p.6237
Main Authors: Percario, Rossana, Panaccio, Paolo, di Mola, Fabio Francesco, Grottola, Tommaso, Di Sebastiano, Pierluigi
Format: Article
Language:English
Subjects:
Bias
Cancer
Carcinogenesis
Clinical trials
Colorectal cancer
Colorectal carcinoma
Environmental factors
Etiology
Hypoxia
Inflammation
Inflammatory bowel disease
Keywords
Literature reviews
Medical prognosis
Microbiota
Pathology
Surgeons
Systematic Review
Tumorigenesis
Vascular endothelial growth factor
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:colorectal cancer (CRC) has a multifactorial etiology which comprises microbiota, genetic predisposition, diet, environmental factors, and last but not least, a substantial contribution by inflammation. The aim of this study is to conduct a systematic review of the literature regarding the strong link between inflammation and colorectal cancer. A systematic review of the literature on PubMed (Medline), Scopus, Cochrane and EMBase databases was performed, following the PRISMA 2020 guidelines. Each paper was reviewed by two groups of researchers in a single-blind format by using a pre-planned Microsoft Excel grid. Using automated research filters, 14,566 studies were included, but 1% was found significant by the reviewers. Seventy pathways of inflammation were described in the sequence of inflammation-carcinogenesis, and anti-tumorigenic molecules were also found. several studies suggest a strong role of inflammation in the tumorigenesis of colorectal cancer through different pathways: this may have a diagnostic and clinical role and also therapeutic purpose in preventing carcinogenesis by treating inflammation. In vitro tests support this theory, even if many other clinical trials are necessary. The present paper was registered in the OpenScience Framework registry (Identifier: DOI 10.17605/OSF.IO/2KG7T).
ISSN:2072-6694
2072-6694
DOI:10.3390/cancers13246237