TRPM7 Ion Channel: Oncogenic Roles and Therapeutic Potential in Breast Cancer

The transient receptor potential melastatin-subfamily member 7 (TRPM7) is a divalent cations permeant channel but also has intrinsic serine/threonine kinase activity. It is ubiquitously expressed in normal tissues and studies have indicated that it participates in important physiological and pharmac...

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Bibliographic Details
Published in:Cancers 2021-12, Vol.13 (24), p.6322
Main Authors: Cordier, Clément, Prevarskaya, Natalia, Lehen'kyi, V'yacheslav
Format: Article
Language:English
Subjects:
Breast cancer
Calcium homeostasis
Calcium signalling
Calcium transport
Cell adhesion & migration
Cell cycle
Cell survival
Embryogenesis
Homeostasis
Kinases
Life Sciences
Magnesium
Mammography
Medical prognosis
Mesenchyme
Mortality
Phosphorylation
Physiology
Prognosis
Prostate
Protein-serine/threonine kinase
Proteins
Review
Roles
Therapeutic applications
Therapeutic targets
Transient receptor potential proteins
Tumors
Womens health
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Summary:The transient receptor potential melastatin-subfamily member 7 (TRPM7) is a divalent cations permeant channel but also has intrinsic serine/threonine kinase activity. It is ubiquitously expressed in normal tissues and studies have indicated that it participates in important physiological and pharmacological processes through its channel-kinase activity, such as calcium/magnesium homeostasis, phosphorylation of proteins involved in embryogenesis or the cellular process. Accumulating evidence has shown that TRPM7 is overexpressed in human pathologies including breast cancer. Breast cancer is the second leading cause of cancer death in women with an incidence rate increase of around 0.5% per year since 2004. The overexpression of TRPM7 may be associated with a poor prognosis in breast cancer patients, so more efforts are needed to research a new therapeutic target. TRPM7 regulates the levels of Ca , which can alter the signaling pathways involved in survival, cell cycle progression, proliferation, growth, migration, invasion, epithelial-mesenchymal transition and thus determines cell behavior, promoting tumor development. This work provides a complete overview of the TRPM7 ion channel and its main involvements in breast cancer. Special consideration is given to the modulation of the channel as a potential target in breast cancer treatment by inhibition of proliferation, migration and invasion. Taken together, these data suggest the potential exploitation of TRPM7 channel-kinase as a therapeutic target and a diagnostic biomarker.
ISSN:2072-6694
2072-6694
DOI:10.3390/cancers13246322