Serpin Family E Member 1 Tag Single-Nucleotide Polymorphisms in Patients with Diabetic Nephropathy: An Association Study and Meta-Analysis Using a Genetic Model-Free Approach

Many lines of evidence highlight the genetic contribution on the development of diabetic nephropathy (DN). One of the studied genes is whose the role in the risk of developing DN remains questionable. In order to elucidate the contribution of in DN progression in the context of type 2 diabetes melli...

Full description

Saved in:
Bibliographic Details
Published in:Genes 2021-11, Vol.12 (12), p.1887
Main Authors: Tziastoudi, Maria, Dardiotis, Efthimios, Pissas, Georgios, Filippidis, Georgios, Golfinopoulos, Spyridon, Siokas, Vasileios, Tachmitzi, Sophia V, Eleftheriadis, Theodoros, Hadjigeorgiou, Georgios M, Tsironi, Evangelia, Stefanidis, Ioannis
Format: Article
Language:English
Subjects:
Aged
Alleles
Case-Control Studies
Creatinine
Cytokines
Diabetes
Diabetes mellitus (non-insulin dependent)
Diabetes Mellitus, Type 2 - genetics
Diabetic Nephropathies - genetics
Female
Gene loci
Genetic analysis
Genetic diversity
Genetic Predisposition to Disease - genetics
Genomes
Genotype
Genotype & phenotype
Humans
Kidney diseases
Male
Meta-analysis
Nephropathy
Odds Ratio
Pathogenesis
Plasminogen Activator Inhibitor 1 - genetics
Polymorphism
Polymorphism, Single Nucleotide - genetics
Population studies
Single-nucleotide polymorphism
Software
White people
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:Many lines of evidence highlight the genetic contribution on the development of diabetic nephropathy (DN). One of the studied genes is whose the role in the risk of developing DN remains questionable. In order to elucidate the contribution of in DN progression in the context of type 2 diabetes mellitus (T2DM), we conducted an association study and meta-analysis of genetic variants. A total of 190 patients with DN, 150 T2DM (type 2 diabetes mellitus) patients without DN and 238 healthy controls were recruited. We selected five tag single-nucleotide polymorphisms (SNPs) from the HapMap. The generalized odds ratio (OR ) was calculated to estimate the risk on DN development. Subgroup analyses based on ethnicity and type of diabetes were also performed. Both the present association study regarding SNPs (rs2227667, rs2070682, rs1050813, rs2227690, rs2227692) did not found any significant association between variants and DN and the meta-analysis of variant 4G>5G (rs1799889) did not also reveal a significant association between 4G>5G variant and DN in main and subgroup analyses. In conclusion, the present association study and meta-analysis provides strong evidence that genetic variant 4G>5G is not implicated in the risk or development of DN in Caucasians. Further studies in other populations remain to further investigate the role of this variant in the course of DN.
ISSN:2073-4425
2073-4425
DOI:10.3390/genes12121887