Drug-Drug Interactions in Vestibular Diseases, Clinical Problems, and Medico-Legal Implications

Peripheral vestibular disease can be treated with several approaches (e.g., maneuvers, surgery, or medical approach). Comorbidity is common in elderly patients, so polytherapy is used, but it can generate the development of drug-drug interactions (DDIs) that play a role in both adverse drug reaction...

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Bibliographic Details
Published in:International journal of environmental research and public health 2021-12, Vol.18 (24), p.12936
Main Authors: Di Mizio, Giulio, Marcianò, Gianmarco, Palleria, Caterina, Muraca, Lucia, Rania, Vincenzo, Roberti, Roberta, Spaziano, Giuseppe, Piscopo, Amalia, Ciconte, Valeria, Di Nunno, Nunzio, Esposito, Massimiliano, Viola, Pasquale, Pisani, Davide, De Sarro, Giovambattista, Raffi, Milena, Piras, Alessandro, Chiarella, Giuseppe, Gallelli, Luca
Format: Article
Language:English
Subjects:
Aged
Benzodiazepines
Comorbidity
Disease
Diuretics
Drug dosages
Drug Interactions
Drug-Related Side Effects and Adverse Reactions - epidemiology
Hearing loss
Histamine
Humans
Malpractice
Maneuvers
Patients
Pharmaceutical Preparations
Pharmacodynamics
Pharmacokinetics
Pharmacology
Physicians
Potassium
Review
Risk management
Side effects
Sodium
Systematic review
Vertigo
Vestibular Diseases - chemically induced
Vestibular system
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Summary:Peripheral vestibular disease can be treated with several approaches (e.g., maneuvers, surgery, or medical approach). Comorbidity is common in elderly patients, so polytherapy is used, but it can generate the development of drug-drug interactions (DDIs) that play a role in both adverse drug reactions and reduced adherence. For this reason, they need a complex kind of approach, considering all their individual characteristics. Physicians must be able to prescribe and deprescribe drugs based on a solid knowledge of pharmacokinetics, pharmacodynamics, and clinical indications. Moreover, full information is required to reach a real therapeutic alliance, to improve the safety of care and reduce possible malpractice claims related to drug-drug interactions. In this review, using PubMed, Embase, and Cochrane library, we searched articles published until 30 August 2021, and described both pharmacokinetic and pharmacodynamic DDIs in patients with vestibular disorders, focusing the interest on their clinical implications and on risk management strategies.
ISSN:1660-4601
1661-7827
1660-4601
DOI:10.3390/ijerph182412936