Effect of Molecular Weight and Nanoarchitecture of Chitosan and Polycaprolactone Electrospun Membranes on Physicochemical and Hemocompatible Properties for Possible Wound Dressing

Tissue engineering has focused on the development of biomaterials that emulate the native extracellular matrix. Therefore, the purpose of this research was oriented to the development of nanofibrillar bilayer membranes composed of polycaprolactone with low and medium molecular weight chitosan, evalu...

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Bibliographic Details
Published in:Polymers 2021-12, Vol.13 (24), p.4320
Main Authors: Oviedo, Maria, Montoya, Yuliet, Agudelo, Wilson, García-García, Alejandra, Bustamante, John
Format: Article
Language:English
Subjects:
Acids
Bilayers
Biocompatibility
Biological properties
Biomedical materials
Biomimetics
Cell growth
Chitosan
Contact angle
Contact stresses
Electrospinning
Extracellular matrix
Fiber orientation
Fourier transforms
Hemolysis
Mechanical properties
Membranes
Modulus of elasticity
Molecular weight
Morphology
Parameters
Permeability
Polycaprolactone
Polymers
Pore size
Spectrum analysis
Stiffness
Tissue engineering
Viscosity
Wettability
Wound healing
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Summary:Tissue engineering has focused on the development of biomaterials that emulate the native extracellular matrix. Therefore, the purpose of this research was oriented to the development of nanofibrillar bilayer membranes composed of polycaprolactone with low and medium molecular weight chitosan, evaluating their physicochemical and biological properties. Two-bilayer membranes were developed by an electrospinning technique considering the effect of chitosan molecular weight and parameter changes in the technique. Subsequently, the membranes were evaluated by scanning electron microscopy, Fourier transform spectroscopy, stress tests, permeability, contact angle, hemolysis evaluation, and an MTT test. From the results, it was found that changes in the electrospinning parameters and the molecular weight of chitosan influence the formation, fiber orientation, and nanoarchitecture of the membranes. Likewise, it was evidenced that a higher molecular weight of chitosan in the bilayer membranes increases the stiffness and favors polar anchor points. This increased Young's modulus, wettability, and permeability, which, in turn, influenced the reduction in the percentage of cell viability and hemolysis. It is concluded that the development of biomimetic bilayer nanofibrillar membranes modulate the physicochemical properties and improve the hemolytic behavior so they can be used as a hemocompatible biomaterial.
ISSN:2073-4360
2073-4360
DOI:10.3390/polym13244320