Microarray analysis to explore the effect of CXCL12 isoforms in a pancreatic pre-tumor cell model

expression was significantly lower in tumor samples than in corresponding normal samples. expression was significantly positively related to the infiltration levels of T cells, dendritic cells (DCs), immature DCs, cytotoxic cells, Tfh cells, mast cells, B cells, Th1 cells, natural killer (NK) cells,...

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Bibliographic Details
Published in:World journal of gastroenterology : WJG 2021-12, Vol.27 (47), p.8194-8198
Main Authors: Miao, Yan-Dong, Wang, Jiang-Tao, Tang, Xiao-Long, Mi, Deng-Hai
Format: Article
Language:English
Subjects:
Chemokine CXCL12
Dendritic Cells
Humans
Killer Cells, Natural
Letter to the Editor
Microarray Analysis
Pancreatic Neoplasms - genetics
Protein Isoforms
Th1 Cells
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Summary:expression was significantly lower in tumor samples than in corresponding normal samples. expression was significantly positively related to the infiltration levels of T cells, dendritic cells (DCs), immature DCs, cytotoxic cells, Tfh cells, mast cells, B cells, Th1 cells, natural killer (NK) cells, pDCs, neutrophils, and T helper cells (Spearman correlation coefficient > 0.5, < 0.001) and negatively correlated with the infiltration level of NK CD56bright cells. In addition, pancreatic hTERT-HPNE cells treated with three diverse isoforms exhibited changes mainly in the regulation of the epithelial-mesenchymal transition activation pathway.
ISSN:1007-9327
2219-2840
DOI:10.3748/wjg.v27.i47.8194