Two-Photon Time-Gated In Vivo Imaging of Dihydrolipoic-Acid-Decorated Gold Nanoclusters

Due to the unique advantages of two-photon technology and time-resolved imaging technology in the biomedical field, attention has been paid to them. Gold clusters possess excellent physicochemical properties and low biotoxicity, which make them greatly advantageous in biological imaging, especially...

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Bibliographic Details
Published in:Materials 2021-12, Vol.14 (24), p.7744
Main Authors: Tian, Ye, Wei, Ming, Wang, Lijun, Hong, Yuankai, Luo, Dan, Sha, Yinlin
Format: Article
Language:English
Subjects:
Absorption cross sections
Biomedical materials
Fluorescence
Gold
Imaging
In vivo methods and tests
Lifetime
Magnetic resonance imaging
Nanoclusters
Photon absorption
Photons
Signal to noise ratio
Tomography
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Summary:Due to the unique advantages of two-photon technology and time-resolved imaging technology in the biomedical field, attention has been paid to them. Gold clusters possess excellent physicochemical properties and low biotoxicity, which make them greatly advantageous in biological imaging, especially for in vivo animal imaging. A gold nanocluster was coupled with dihydrolipoic acid to obtain a functionalized nanoprobe; the material displayed significant features, including a large two-photon absorption cross-section (up to 1.59 × 10 GM) and prolonged fluorescence lifetime (>300 ns). The two-photon and time-resolution techniques were used to perform cell imaging and in vivo imaging.
ISSN:1996-1944
1996-1944
DOI:10.3390/ma14247744