Evaluation of the Roche-SD Biosensor rapid antigen test: Antigen is not reliable in detecting SARS-CoV-2 at the early stage of infection with respiratory symptoms

We evaluated a rapid antigen test against SARS-CoV-2 virus (Roche-SD Biosensor; RSDB-RAT) in children and adults with respiratory symptoms compared to those with nonrespiratory symptoms or asymptomatic. Also the performance of RSDB-RAT with respect to the duration of respiratory symptoms was assesse...

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Bibliographic Details
Published in:Diagnostic microbiology and infectious disease 2022-04, Vol.102 (4), p.115628-115628, Article 115628
Main Authors: Flinck, Heini, Kerimov, Dominik, Luukinen, Bruno, Seiskari, Tapio, Aittoniemi, Janne
Format: Article
Language:English
Subjects:
Antigens, Viral
Biosensing Techniques
COVID-19
COVID-19 - diagnosis
Humans
Rapid antigen test
SARS-CoV-2
Sensitivity and Specificity
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Summary:We evaluated a rapid antigen test against SARS-CoV-2 virus (Roche-SD Biosensor; RSDB-RAT) in children and adults with respiratory symptoms compared to those with nonrespiratory symptoms or asymptomatic. Also the performance of RSDB-RAT with respect to the duration of respiratory symptoms was assessed. A viral cross-reactivity panel was included. RSDB-RAT was reliable in detecting SARS-CoV-2 in children and adults if the respiratory symptoms had endured 1 to 7 days. If the respiratory symptoms had lasted less than 1 day, the sensitivity was significantly lower. No cross-reactivity with other respiratory viruses was observed.
ISSN:0732-8893
1879-0070
DOI:10.1016/j.diagmicrobio.2021.115628