Recent advances in the protective role of metallic nanoparticles in red blood cells

The interaction of nanoparticles with the biological system has increased with the increasing popularity of nanomedicines. Red blood cells (RBCs) are very sensitive, and abundant cells in the blood. They are highly prone to oxidative damage due to constant interaction with oxygen itself, foreign par...

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Bibliographic Details
Published in:3 Biotech 2022-01, Vol.12 (1), p.28-28, Article 28
Main Authors: Yadav, Somu, Maurya, Pawan Kumar
Format: Article
Language:English
Subjects:
Agriculture
Antioxidants
Bioinformatics
Biomaterials
Biotechnology
Cancer Research
Cell membranes
Chemistry
Chemistry and Materials Science
Deformability
Erythrocytes
Formability
Heme
Hemoglobin
Life span
Lipid peroxidation
Lipids
Membrane permeability
Morphology
Nanoparticles
Oxidation
Oxidative stress
Review
Review Article
Stem Cells
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Summary:The interaction of nanoparticles with the biological system has increased with the increasing popularity of nanomedicines. Red blood cells (RBCs) are very sensitive, and abundant cells in the blood. They are highly prone to oxidative damage due to constant interaction with oxygen itself, foreign particles in the blood, and the lack of repair mechanism. The cell membrane of RBCs undergoes lipid peroxidation, protein oxidation, and heme degradation which results in altered membrane permeability, changes in the morphology, and functioning of RBCs. The nanoparticles induce oxidative stress, hemolysis, morphological changes, membrane deformability, and alterations in hemoglobin structure in RBCs. In this review, the effects of metallic nanoparticles and their modifications on the physiology, and life span of RBCs are discussed. The detailed analysis of the antioxidant enzymes-like activity of metal nanoparticles is expected to highlight the beneficial use of these metal nanoparticles in RBCs against oxidative stress and the development of new biosafe nanodrugs.
ISSN:2190-572X
2190-5738
DOI:10.1007/s13205-021-03087-x