Predictive value of using plasma long non‑coding RNAs ANRIL and HOXA11‑AS for in‑stent restenosis

In-stent restenosis (ISR) can pose serious challenges for cardiologists following coronary stent implantation. Early identification of patients at high risk of ISR is considered to be effective for its prevention. However, factors that can reliably predict the risk of ISR remain elusive at present....

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Bibliographic Details
Published in:Experimental and therapeutic medicine 2022-02, Vol.23 (2), Article 115
Main Authors: Jin, Zhijiang, Shen, Hongfeng, Cha, Wei, Xia, Haijiang, Liu, Longbin
Format: Article
Language:English
Subjects:
Angioplasty
Cardiovascular disease
Care and treatment
Complications and side effects
Coronary heart disease
Coronary restenosis
Coronary vessels
Diabetes
Endovascular stents
Genetic aspects
Health aspects
Heart
Hospitals
Hypertension
Leukemia
Medical imaging
Physiological aspects
Plasma
Prognosis
Risk factors
RNA
Smooth muscle
Stents
Transcription factors
Veins & arteries
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Summary:In-stent restenosis (ISR) can pose serious challenges for cardiologists following coronary stent implantation. Early identification of patients at high risk of ISR is considered to be effective for its prevention. However, factors that can reliably predict the risk of ISR remain elusive at present. The present study aimed to investigate the possible association between plasma long non-coding RNA (lncRNA) levels and ISR. A total of 410 patients with single-vessel lesion who received drug-eluting stents (DES) were included in the present study. After 12-36 months of follow-up, coronary angiography was performed and ISR was defined as >50% diameter stenosis at follow-up. RT-qPCR was used to measure lncRNA expression. Expression of the lncRNA RNA antisense non-coding RNA at the INK4 locus (ANRIL) was found to be upregulated whereas the lncRNA homeobox A11 antisense (HOXA11-AS) was downregulated in the plasma of patients with ISR compared with that from patients without ISR (P
ISSN:1792-0981
1792-1015
DOI:10.3892/etm.2021.11038