Salvianolic acid B inhibits the progression of liver fibrosis in rats via modulation of the Hedgehog signaling pathway

Salvianolic acid B (Sal B) has previously reported anti-hepatic fibrosis effects, though it is not clear if it can inhibit hepatic fibrosis by regulating the hedgehog (Hh) signaling pathway. The aim of the present study was to explore the roles and mechanism of Sal B in preventing and treating liver...

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Bibliographic Details
Published in:Experimental and therapeutic medicine 2022-02, Vol.23 (2), Article 116
Main Authors: Tao, Shanjun, Duan, Renjie, Xu, Tong, Hong, Jiao, Gu, Wenjie, Lin, Aiqin, Lian, Likai, Huang, Haoyu, Lu, Jiangtao, Li, Tiechen
Format: Article
Language:English
Subjects:
Abdomen
Alcohol
Antibodies
Care and treatment
Cellular signal transduction
Chemical properties
Coronary vessels
Development and progression
Fibrosis
Growth factors
Health aspects
Laboratory animals
Liver cancer
Liver diseases
Medical research
Membranes
Physiological aspects
Phytochemicals
Proteins
Salvia
Science
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Summary:Salvianolic acid B (Sal B) has previously reported anti-hepatic fibrosis effects, though it is not clear if it can inhibit hepatic fibrosis by regulating the hedgehog (Hh) signaling pathway. The aim of the present study was to explore the roles and mechanism of Sal B in preventing and treating liver fibrosis in rats. The study also aimed to determine the role of the Hh signaling pathway in this process. A rat model of liver fibrosis was induced through the subcutaneous injection of 50% carbon tetrachloride, followed by treatment with Sal B. After gavage, blood was collected to detect serum markers of liver injury. The degree of liver fibrosis and tissue damage was assessed using histopathological analysis. Western blotting and reverse transcription-quantitative PCR were used to detect the expression levels of TGF-[beta]1 and Hh signaling pathway-related genes, including Sonic hedgehog (Shh) protein, membrane protein receptor protein patched homolog 1 (Ptch1), membrane protein receptor Smoothened (Smo) and transcription factor glioma-associated oncogene homolog 1 (Gli1). Serum alanine aminotransferase, aspartate aminotransferase and total bilirubin levels were decreased, whilst levels of albumin were increased in rats with liver fibrosis that were treated with Sal B (P
ISSN:1792-0981
1792-1015
DOI:10.3892/etm.2021.11039