The changing epidemiology of hepatocellular carcinoma in Greece

Hepatocellular carcinoma (HCC) is the sixth most common cancer globally, and is attributable mainly to viral hepatitis, alcohol and nonalcoholic fatty liver disease. Three hundred Greek patients diagnosed with HCC between 2000 and 2019 were retrospectively evaluated for patient and HCC characteristi...

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Published in:Annals of gastroenterology 2022-01, Vol.35 (1), p.88-94
Main Authors: Markakis, George E, Koulouris, Andreas, Tampaki, Maria, Cholongitas, Evangelos, Deutsch, Melanie, Papatheodoridis, George V, Koskinas, John
Format: Article
Language:English
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Summary:Hepatocellular carcinoma (HCC) is the sixth most common cancer globally, and is attributable mainly to viral hepatitis, alcohol and nonalcoholic fatty liver disease. Three hundred Greek patients diagnosed with HCC between 2000 and 2019 were retrospectively evaluated for patient and HCC characteristics. Patients were classified as before 2011 (A) or after 2011 (B) and HCC risk factors were compared with historic Greek cohorts. The median age was 64 years and 86% were male; 45% had chronic hepatitis B virus (HBV) infection, 26% chronic hepatitis C virus (HCV) infection, and 30% non-viral liver diseases (nvLD). No change was observed among liver diseases between periods A and B. However, there was a trend towards a decrease in virally and an increase in non-virally induced HCC (P=0.075). Patients in period B (vs. A) were more likely to be diagnosed with fewer (
ISSN:1108-7471
1792-7463
1792-7463
DOI:10.20524/aog.2021.0680