Unravelling multiple removal pathways of oseltamivir in wastewater by microalgae through experimentation and computation

Increased worldwide consumption of antiviral drugs (AVDs) amid COVID-19 has induced enormous burdens to the existing wastewater treatment systems. Microalgae-based bioremediation is a competitive alternative technology due to its simultaneous nutrient recovery and sustainable biomass production. How...

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Bibliographic Details
Published in:Journal of hazardous materials 2022-04, Vol.427, p.128139-128139, Article 128139
Main Authors: Zeeshan, Qasim M., Qiu, Shuang, Gu, Jia, Abbew, Abdul-Wahab, Wu, Zhengshuai, Chen, Zhipeng, Xu, Sai, Ge, Shijian
Format: Article
Language:English
Subjects:
Antiviral drugs
Biodegradation
Biomass
Chlorella
Chlorella sorkiniana
COVID-19
Extracellular polymeric substances
Humans
Microalgae
Oseltamivir
Quantum chemical calculation
SARS-CoV-2
Wastewater
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Summary:Increased worldwide consumption of antiviral drugs (AVDs) amid COVID-19 has induced enormous burdens to the existing wastewater treatment systems. Microalgae-based bioremediation is a competitive alternative technology due to its simultaneous nutrient recovery and sustainable biomass production. However, knowledge about the fate, distribution, and interaction of AVDs with microalgae is yet to be determined. In this study, a concentration-determined influence of AVD oseltamivir (OT) was observed on the biochemical pathway of Chlorella sorkiniana (C.S-N1) in synthetic municipal wastewater. The results showed that high OT concentration inhibited biomass growth through increased oxidative stress and restrained photosynthesis. Nevertheless, complete OT removal was achieved at its optimized concentration of 10 mg/L by various biotic (82%) and abiotic processes (18.0%). The chemical alterations in three subtypes of extracellular polymeric substances (EPS) were primarily investigated by electrostatic (OT +8.22 mV vs. C.S-N1 −18.31 mV) and hydrophobic interactions between EPS-OT complexes supported by secondary structure protein analysis. Besides, six biodegradation-catalyzed transformation products were identified by quadrupole-time-of-flight mass spectrometer and by density functional theory. Moreover, all the TPs exhibited log Kow ≤ 5 and bioconcentration factor values of
ISSN:0304-3894
1873-3336
DOI:10.1016/j.jhazmat.2021.128139