Prediction errors disrupt hippocampal representations and update episodic memories

• Published in: Proceedings of the National Academy of Sciences - PNAS 2021-12, Vol.118 (51), p.1-12
• Main Authors: Sinclair, Alyssa H., Manalili, Grace M., Brunec, Iva K., Adcock, R. Alison, Barense, Morgan D.
• Format: Article
• Language: English
• Subjects: Adolescent; Adult; Basal forebrain; Biological Sciences; Cholinergics; Error signals; Female; Forebrain; Functional magnetic resonance imaging; Hippocampus; Hippocampus - physiology; Humans; Learning; Magnetic Resonance Imaging; Male; Memory; Memory, Episodic; Mental Recall - physiology; Middle Aged; Nerve Net; Neural networks; Predictions; Prosencephalon - physiology; Representations; Young Adult
• ISSN: 0027-8424; 1091-6490
• DOI: 10.1073/pnas.2117625118

The brain supports adaptive behavior by generating predictions, learning from errors, and updating memories to incorporate new information. Prediction error, or surprise, triggers learning when reality contradicts expectations. Prior studies have shown that the hippocampus signals prediction errors, but the hypothesized link to memory updating has not been demonstrated. In a human functional MRI study, we elicited mnemonic prediction errors by interrupting familiar narrative videos immediately before the expected endings. We found that prediction errors reversed the relationship between univariate hippocampal activation and memory: greater hippocampal activation predicted memory preservation after expected endings, but memory updating after surprising endings. In contrast to previous studies, we show that univariate activation was insufficient for understanding hippocampal prediction error signals. We explain this surprising finding by tracking both the evolution of hippocampal activation patterns and the connectivity between the hippocampus and neuromodulatory regions. We found that hippocampal activation patterns stabilized as each narrative episode unfolded, suggesting sustained episodic representations. Prediction errors disrupted these sustained representations and the degree of disruption predicted memory updating. The relationship between hippocampal activation and subsequent memory depended on concurrent basal forebrain activation, supporting the idea that cholinergic modulation regulates attention and memory. We conclude that prediction errors create conditions that favor memory updating, prompting the hippocampus to abandon ongoing predictions and make memories malleable.