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High-Frequency Three-Dimensional Lumen Volume Ultrasound Is a Sensitive Method to Detect Early Aneurysmal Change in Elastase-Induced Murine Abdominal Aortic Aneurysm
Abstract Objective The aim of this study was to investigate the reproducibility of anterior–posterior diameter (APd max ) and three-dimensional lumen volume (3DLV) measurements of abdominal aortic aneurysms (AAA) in a classical murine AAA model. We also compared the magnitude of change in the aorti...
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Published in: | Aorta (Stamford, Conn.) Conn.), 2021-12, Vol.9 (6), p.215-220 |
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container_title | Aorta (Stamford, Conn.) |
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creator | Waduud, Mohammed A. Kandavelu, Parkavi Reay, Melanie Paradine, Katherine Scott, David J. A. Bailey, Marc A. |
description | Abstract
Objective
The aim of this study was to investigate the reproducibility of anterior–posterior diameter (APd
max
) and three-dimensional lumen volume (3DLV) measurements of abdominal aortic aneurysms (AAA) in a classical murine AAA model. We also compared the magnitude of change in the aortic size detected with each method of assessment.
Methods
Periadventitial application of porcine pancreatic elastase (PPE AAA) or sham surgery was performed in two cohorts of mice. Cohort 1 was used to assess for observer variability with the APd
max
and 3DLV measurements. Cohort 2 highlighted the relationship between APd
max
and 3DLV and changes in AAA detected.
Results
There was no significant observer variability detected with APd
max
measurement. Similarly, no significant intraobserver variability was evident with 3DLV; however, a small but significant interobserver difference was present. APd
max
and 3DLV measurements of PPE AAA significantly correlated. However, changes in the AAA morphology were detected earlier with 3DLV.
Conclusion
APd
max
and 3DLV are both reliable methods for measuring an AAA. Both these methods correlate with each other. However, changes in AAA morphology were detected earlier with 3DLV, which is important to detect subtle but important changes to aortic geometry in a laboratory setting. 3DLV measurement of AAA is a simple, reproducible, and comprehensive method for assessing changes in disease morphology. |
doi_str_mv | 10.1055/s-0041-1731404 |
format | article |
fullrecord | <record><control><sourceid>proquest_pubme</sourceid><recordid>TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_8714318</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>2615302035</sourcerecordid><originalsourceid>FETCH-LOGICAL-c3434-97a0be2058283102bbd0790ed1b2c536fa7326c21f318acebaf35154177e96313</originalsourceid><addsrcrecordid>eNp1kU9PGzEQxS3UChBw7bHysReD_-1ucqkUhQCRgjgUerW83tms0a5NbS9SPlC_Z71KGtFDfZmR_OY39nsIfWH0mtGiuImEUskIqwSTVJ6gcy54QWQpqk8f-jN0FeMrzWcuOS3lKToTcl4KVrJz9PvBbjtyF-DXCM7s8HMXAMitHcBF653u8WbMPf7p-1zxS5-Cjn50DV5HrPGPSZbsO-BHSJ1vcPL4FhKYhFc69Du8cDCGXRwyaNlptwVsHV71OiYdgaxdMxpo8OMYrAO8qBs_2GnpwodkzXH6En1udR_h6lAv0Mvd6nn5QDZP9-vlYkOMkEKSeaVpDZwWMz4TjPK6bmg1p9CwmptClK2uBC8NZ61gM22g1q0oWCFZVcFkiLhA3_fct7EeoDHg8nd79RbsoMNOeW3VvzfOdmrr39WsYjIzM-DbARB8djQmNdhooO-1Az9GxUtWCMqpKLL0ei81wccYoD2uYVRN8aqopnjVId488PXj447yv2FmAdkLUmdhAPXqx5DNjP8D_gFkoLBu</addsrcrecordid><sourcetype>Open Access Repository</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>2615302035</pqid></control><display><type>article</type><title>High-Frequency Three-Dimensional Lumen Volume Ultrasound Is a Sensitive Method to Detect Early Aneurysmal Change in Elastase-Induced Murine Abdominal Aortic Aneurysm</title><source>PubMed Central</source><source>Thieme Connect Journals Open Access</source><creator>Waduud, Mohammed A. ; Kandavelu, Parkavi ; Reay, Melanie ; Paradine, Katherine ; Scott, David J. A. ; Bailey, Marc A.</creator><creatorcontrib>Waduud, Mohammed A. ; Kandavelu, Parkavi ; Reay, Melanie ; Paradine, Katherine ; Scott, David J. A. ; Bailey, Marc A.</creatorcontrib><description>Abstract
Objective
The aim of this study was to investigate the reproducibility of anterior–posterior diameter (APd
max
) and three-dimensional lumen volume (3DLV) measurements of abdominal aortic aneurysms (AAA) in a classical murine AAA model. We also compared the magnitude of change in the aortic size detected with each method of assessment.
Methods
Periadventitial application of porcine pancreatic elastase (PPE AAA) or sham surgery was performed in two cohorts of mice. Cohort 1 was used to assess for observer variability with the APd
max
and 3DLV measurements. Cohort 2 highlighted the relationship between APd
max
and 3DLV and changes in AAA detected.
Results
There was no significant observer variability detected with APd
max
measurement. Similarly, no significant intraobserver variability was evident with 3DLV; however, a small but significant interobserver difference was present. APd
max
and 3DLV measurements of PPE AAA significantly correlated. However, changes in the AAA morphology were detected earlier with 3DLV.
Conclusion
APd
max
and 3DLV are both reliable methods for measuring an AAA. Both these methods correlate with each other. However, changes in AAA morphology were detected earlier with 3DLV, which is important to detect subtle but important changes to aortic geometry in a laboratory setting. 3DLV measurement of AAA is a simple, reproducible, and comprehensive method for assessing changes in disease morphology.</description><identifier>ISSN: 2325-4637</identifier><identifier>EISSN: 2325-4637</identifier><identifier>DOI: 10.1055/s-0041-1731404</identifier><identifier>PMID: 34963161</identifier><language>eng</language><publisher>333 Seventh Avenue, 18th Floor, New York, NY 10001, USA: Thieme Medical Publishers, Inc</publisher><subject>Original ; Original Research Article</subject><ispartof>Aorta (Stamford, Conn.), 2021-12, Vol.9 (6), p.215-220</ispartof><rights>The Author(s). This is an open access article published by Thieme under the terms of the Creative Commons Attribution License, permitting unrestricted use, distribution, and reproduction so long as the original work is properly cited.</rights><rights>The Author(s). This is an open access article published by Thieme under the terms of the Creative Commons Attribution License, permitting unrestricted use, distribution, and reproduction so long as the original work is properly cited. (https://creativecommons.org/licenses/by/4.0/).</rights><rights>The Author(s). This is an open access article published by Thieme under the terms of the Creative Commons Attribution License, permitting unrestricted use, distribution, and reproduction so long as the original work is properly cited. ( ) 2021 The Author(s).</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c3434-97a0be2058283102bbd0790ed1b2c536fa7326c21f318acebaf35154177e96313</citedby><cites>FETCH-LOGICAL-c3434-97a0be2058283102bbd0790ed1b2c536fa7326c21f318acebaf35154177e96313</cites><orcidid>0000-0001-5567-9952 ; 0000-0002-7562-0277</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC8714318/pdf/$$EPDF$$P50$$Gpubmedcentral$$Hfree_for_read</linktopdf><linktohtml>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC8714318/$$EHTML$$P50$$Gpubmedcentral$$Hfree_for_read</linktohtml><link.rule.ids>230,314,727,780,784,885,20891,27924,27925,53791,53793,54587,54615</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/34963161$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Waduud, Mohammed A.</creatorcontrib><creatorcontrib>Kandavelu, Parkavi</creatorcontrib><creatorcontrib>Reay, Melanie</creatorcontrib><creatorcontrib>Paradine, Katherine</creatorcontrib><creatorcontrib>Scott, David J. A.</creatorcontrib><creatorcontrib>Bailey, Marc A.</creatorcontrib><title>High-Frequency Three-Dimensional Lumen Volume Ultrasound Is a Sensitive Method to Detect Early Aneurysmal Change in Elastase-Induced Murine Abdominal Aortic Aneurysm</title><title>Aorta (Stamford, Conn.)</title><addtitle>Aorta (Stamford)</addtitle><description>Abstract
Objective
The aim of this study was to investigate the reproducibility of anterior–posterior diameter (APd
max
) and three-dimensional lumen volume (3DLV) measurements of abdominal aortic aneurysms (AAA) in a classical murine AAA model. We also compared the magnitude of change in the aortic size detected with each method of assessment.
Methods
Periadventitial application of porcine pancreatic elastase (PPE AAA) or sham surgery was performed in two cohorts of mice. Cohort 1 was used to assess for observer variability with the APd
max
and 3DLV measurements. Cohort 2 highlighted the relationship between APd
max
and 3DLV and changes in AAA detected.
Results
There was no significant observer variability detected with APd
max
measurement. Similarly, no significant intraobserver variability was evident with 3DLV; however, a small but significant interobserver difference was present. APd
max
and 3DLV measurements of PPE AAA significantly correlated. However, changes in the AAA morphology were detected earlier with 3DLV.
Conclusion
APd
max
and 3DLV are both reliable methods for measuring an AAA. Both these methods correlate with each other. However, changes in AAA morphology were detected earlier with 3DLV, which is important to detect subtle but important changes to aortic geometry in a laboratory setting. 3DLV measurement of AAA is a simple, reproducible, and comprehensive method for assessing changes in disease morphology.</description><subject>Original</subject><subject>Original Research Article</subject><issn>2325-4637</issn><issn>2325-4637</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2021</creationdate><recordtype>article</recordtype><sourceid>0U6</sourceid><recordid>eNp1kU9PGzEQxS3UChBw7bHysReD_-1ucqkUhQCRgjgUerW83tms0a5NbS9SPlC_Z71KGtFDfZmR_OY39nsIfWH0mtGiuImEUskIqwSTVJ6gcy54QWQpqk8f-jN0FeMrzWcuOS3lKToTcl4KVrJz9PvBbjtyF-DXCM7s8HMXAMitHcBF653u8WbMPf7p-1zxS5-Cjn50DV5HrPGPSZbsO-BHSJ1vcPL4FhKYhFc69Du8cDCGXRwyaNlptwVsHV71OiYdgaxdMxpo8OMYrAO8qBs_2GnpwodkzXH6En1udR_h6lAv0Mvd6nn5QDZP9-vlYkOMkEKSeaVpDZwWMz4TjPK6bmg1p9CwmptClK2uBC8NZ61gM22g1q0oWCFZVcFkiLhA3_fct7EeoDHg8nd79RbsoMNOeW3VvzfOdmrr39WsYjIzM-DbARB8djQmNdhooO-1Az9GxUtWCMqpKLL0ei81wccYoD2uYVRN8aqopnjVId488PXj447yv2FmAdkLUmdhAPXqx5DNjP8D_gFkoLBu</recordid><startdate>202112</startdate><enddate>202112</enddate><creator>Waduud, Mohammed A.</creator><creator>Kandavelu, Parkavi</creator><creator>Reay, Melanie</creator><creator>Paradine, Katherine</creator><creator>Scott, David J. A.</creator><creator>Bailey, Marc A.</creator><general>Thieme Medical Publishers, Inc</general><scope>0U6</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope><scope>5PM</scope><orcidid>https://orcid.org/0000-0001-5567-9952</orcidid><orcidid>https://orcid.org/0000-0002-7562-0277</orcidid></search><sort><creationdate>202112</creationdate><title>High-Frequency Three-Dimensional Lumen Volume Ultrasound Is a Sensitive Method to Detect Early Aneurysmal Change in Elastase-Induced Murine Abdominal Aortic Aneurysm</title><author>Waduud, Mohammed A. ; Kandavelu, Parkavi ; Reay, Melanie ; Paradine, Katherine ; Scott, David J. A. ; Bailey, Marc A.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c3434-97a0be2058283102bbd0790ed1b2c536fa7326c21f318acebaf35154177e96313</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2021</creationdate><topic>Original</topic><topic>Original Research Article</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Waduud, Mohammed A.</creatorcontrib><creatorcontrib>Kandavelu, Parkavi</creatorcontrib><creatorcontrib>Reay, Melanie</creatorcontrib><creatorcontrib>Paradine, Katherine</creatorcontrib><creatorcontrib>Scott, David J. A.</creatorcontrib><creatorcontrib>Bailey, Marc A.</creatorcontrib><collection>Thieme Connect Journals Open Access</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>Aorta (Stamford, Conn.)</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Waduud, Mohammed A.</au><au>Kandavelu, Parkavi</au><au>Reay, Melanie</au><au>Paradine, Katherine</au><au>Scott, David J. A.</au><au>Bailey, Marc A.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>High-Frequency Three-Dimensional Lumen Volume Ultrasound Is a Sensitive Method to Detect Early Aneurysmal Change in Elastase-Induced Murine Abdominal Aortic Aneurysm</atitle><jtitle>Aorta (Stamford, Conn.)</jtitle><addtitle>Aorta (Stamford)</addtitle><date>2021-12</date><risdate>2021</risdate><volume>9</volume><issue>6</issue><spage>215</spage><epage>220</epage><pages>215-220</pages><issn>2325-4637</issn><eissn>2325-4637</eissn><abstract>Abstract
Objective
The aim of this study was to investigate the reproducibility of anterior–posterior diameter (APd
max
) and three-dimensional lumen volume (3DLV) measurements of abdominal aortic aneurysms (AAA) in a classical murine AAA model. We also compared the magnitude of change in the aortic size detected with each method of assessment.
Methods
Periadventitial application of porcine pancreatic elastase (PPE AAA) or sham surgery was performed in two cohorts of mice. Cohort 1 was used to assess for observer variability with the APd
max
and 3DLV measurements. Cohort 2 highlighted the relationship between APd
max
and 3DLV and changes in AAA detected.
Results
There was no significant observer variability detected with APd
max
measurement. Similarly, no significant intraobserver variability was evident with 3DLV; however, a small but significant interobserver difference was present. APd
max
and 3DLV measurements of PPE AAA significantly correlated. However, changes in the AAA morphology were detected earlier with 3DLV.
Conclusion
APd
max
and 3DLV are both reliable methods for measuring an AAA. Both these methods correlate with each other. However, changes in AAA morphology were detected earlier with 3DLV, which is important to detect subtle but important changes to aortic geometry in a laboratory setting. 3DLV measurement of AAA is a simple, reproducible, and comprehensive method for assessing changes in disease morphology.</abstract><cop>333 Seventh Avenue, 18th Floor, New York, NY 10001, USA</cop><pub>Thieme Medical Publishers, Inc</pub><pmid>34963161</pmid><doi>10.1055/s-0041-1731404</doi><tpages>6</tpages><orcidid>https://orcid.org/0000-0001-5567-9952</orcidid><orcidid>https://orcid.org/0000-0002-7562-0277</orcidid><oa>free_for_read</oa></addata></record> |
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title | High-Frequency Three-Dimensional Lumen Volume Ultrasound Is a Sensitive Method to Detect Early Aneurysmal Change in Elastase-Induced Murine Abdominal Aortic Aneurysm |
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