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High-Frequency Three-Dimensional Lumen Volume Ultrasound Is a Sensitive Method to Detect Early Aneurysmal Change in Elastase-Induced Murine Abdominal Aortic Aneurysm

Abstract Objective  The aim of this study was to investigate the reproducibility of anterior–posterior diameter (APd max ) and three-dimensional lumen volume (3DLV) measurements of abdominal aortic aneurysms (AAA) in a classical murine AAA model. We also compared the magnitude of change in the aorti...

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Published in:Aorta (Stamford, Conn.) Conn.), 2021-12, Vol.9 (6), p.215-220
Main Authors: Waduud, Mohammed A., Kandavelu, Parkavi, Reay, Melanie, Paradine, Katherine, Scott, David J. A., Bailey, Marc A.
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container_end_page 220
container_issue 6
container_start_page 215
container_title Aorta (Stamford, Conn.)
container_volume 9
creator Waduud, Mohammed A.
Kandavelu, Parkavi
Reay, Melanie
Paradine, Katherine
Scott, David J. A.
Bailey, Marc A.
description Abstract Objective  The aim of this study was to investigate the reproducibility of anterior–posterior diameter (APd max ) and three-dimensional lumen volume (3DLV) measurements of abdominal aortic aneurysms (AAA) in a classical murine AAA model. We also compared the magnitude of change in the aortic size detected with each method of assessment. Methods  Periadventitial application of porcine pancreatic elastase (PPE AAA) or sham surgery was performed in two cohorts of mice. Cohort 1 was used to assess for observer variability with the APd max and 3DLV measurements. Cohort 2 highlighted the relationship between APd max and 3DLV and changes in AAA detected. Results  There was no significant observer variability detected with APd max measurement. Similarly, no significant intraobserver variability was evident with 3DLV; however, a small but significant interobserver difference was present. APd max and 3DLV measurements of PPE AAA significantly correlated. However, changes in the AAA morphology were detected earlier with 3DLV. Conclusion  APd max and 3DLV are both reliable methods for measuring an AAA. Both these methods correlate with each other. However, changes in AAA morphology were detected earlier with 3DLV, which is important to detect subtle but important changes to aortic geometry in a laboratory setting. 3DLV measurement of AAA is a simple, reproducible, and comprehensive method for assessing changes in disease morphology.
doi_str_mv 10.1055/s-0041-1731404
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Similarly, no significant intraobserver variability was evident with 3DLV; however, a small but significant interobserver difference was present. APd max and 3DLV measurements of PPE AAA significantly correlated. However, changes in the AAA morphology were detected earlier with 3DLV. Conclusion  APd max and 3DLV are both reliable methods for measuring an AAA. Both these methods correlate with each other. However, changes in AAA morphology were detected earlier with 3DLV, which is important to detect subtle but important changes to aortic geometry in a laboratory setting. 3DLV measurement of AAA is a simple, reproducible, and comprehensive method for assessing changes in disease morphology.</description><identifier>ISSN: 2325-4637</identifier><identifier>EISSN: 2325-4637</identifier><identifier>DOI: 10.1055/s-0041-1731404</identifier><identifier>PMID: 34963161</identifier><language>eng</language><publisher>333 Seventh Avenue, 18th Floor, New York, NY 10001, USA: Thieme Medical Publishers, Inc</publisher><subject>Original ; Original Research Article</subject><ispartof>Aorta (Stamford, Conn.), 2021-12, Vol.9 (6), p.215-220</ispartof><rights>The Author(s). 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A.</creatorcontrib><creatorcontrib>Bailey, Marc A.</creatorcontrib><collection>Thieme Connect Journals Open Access</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>Aorta (Stamford, Conn.)</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Waduud, Mohammed A.</au><au>Kandavelu, Parkavi</au><au>Reay, Melanie</au><au>Paradine, Katherine</au><au>Scott, David J. 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title High-Frequency Three-Dimensional Lumen Volume Ultrasound Is a Sensitive Method to Detect Early Aneurysmal Change in Elastase-Induced Murine Abdominal Aortic Aneurysm
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