Palmitoylation in Crohn's disease: Current status and future directions

S-palmitoylation is one of the most common post-translational modifications in nature; however, its importance has been overlooked for decades. Crohn's disease (CD), a subtype of inflammatory bowel disease (IBD), is an autoimmune disease characterized by chronic inflammation involving the entir...

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Published in:World journal of gastroenterology : WJG 2021-12, Vol.27 (48), p.8201-8215
Main Authors: Cheng, Wei-Xin, Ren, Yue, Lu, Miao-Miao, Xu, Ling-Ling, Gao, Jian-Guo, Chen, Dong, Kalyani, Farhin Shaheed, Lv, Zi-Yan, Chen, Chun-Xiao, Ji, Feng, Lin, He-Ning, Jin, Xi
Format: Article
Language:English
Subjects:
Crohn Disease - diagnosis
Crohn Disease - epidemiology
Crohn Disease - genetics
Frontier
Gastrointestinal Microbiome
Humans
Inflammatory Bowel Diseases
Lipoylation
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Summary:S-palmitoylation is one of the most common post-translational modifications in nature; however, its importance has been overlooked for decades. Crohn's disease (CD), a subtype of inflammatory bowel disease (IBD), is an autoimmune disease characterized by chronic inflammation involving the entire gastrointestinal tract. Bowel damage and subsequent disabilities caused by CD are a growing global health issue. Well-acknowledged risk factors for CD include genetic susceptibility, environmental factors, such as a westernized lifestyle, and altered gut microbiota. However, the pathophysiological mechanisms of this disorder are not yet comprehensively understood. With the rapidly increasing global prevalence of CD and the evident role of S-palmitoylation in CD, as recently reported, there is a need to investigate the relationship between CD and S-palmitoylation. In this review, we summarize the concept, detection, and function of S-palmitoylation as well as its potential effects on CD, and provide novel insights into the pathogenesis and treatment of CD.
ISSN:1007-9327
2219-2840
DOI:10.3748/wjg.v27.i48.8201