Clinicopathological and Prognostic Significance of ABCC3 in Human Glioma

Glioma is the most common malignant primary brain tumor with an inferior survival period and unsatisfactory prognoses. Identification of novel biomarkers is important for the improvements of clinical outcomes of glioma patients. In recent years, more and more biomarkers were identified in many types...

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Published in:Journal of oncology 2021-12, Vol.2021, p.1827992-8
Main Authors: Fang, Dan-Dong, Huang, Wei, Cheng, Gang, Liu, Xiao-Nan, Liu, Shi-Min, Hou, Bao-Sen, Mao, Jian, Zhou, Hu
Format: Article
Language:English
Subjects:
Analysis
Biomarkers
Brain tumors
Cancer
Cancer therapies
Chemotherapy
Diagnosis
Genes
Glioma
Gliomas
Medical prognosis
Metastasis
Prognosis
Survival analysis
Tumors
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creator Fang, Dan-Dong
Huang, Wei
Cheng, Gang
Liu, Xiao-Nan
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Hou, Bao-Sen
Mao, Jian
Zhou, Hu
description Glioma is the most common malignant primary brain tumor with an inferior survival period and unsatisfactory prognoses. Identification of novel biomarkers is important for the improvements of clinical outcomes of glioma patients. In recent years, more and more biomarkers were identified in many types of tumors. However, the sensitive markers for diagnoses and prognoses of patients with glioma remained unknown. In the present research, our team intended to explore the expression and clinical significance of ABCC3 in glioma patients. Sequential data filtration (survival analyses, independent prognosis analyses, ROC curve analyses, and clinical association analyses) was completed, which gave rise to the determination of the relationship between glioma and the ABCC3 gene. Clinical assays on the foundation of CGGA and TCGA datasets unveiled that ABCC3 expression was distinctly upregulated in glioma and predicted a shorter overall survival. In the multivariable Cox analysis, our team discovered that the expression of ABCC3 was an independent prognosis marker for both 5-year OS (HR = 1.118, 95% CI: 1.052–1.188; P
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Identification of novel biomarkers is important for the improvements of clinical outcomes of glioma patients. In recent years, more and more biomarkers were identified in many types of tumors. However, the sensitive markers for diagnoses and prognoses of patients with glioma remained unknown. In the present research, our team intended to explore the expression and clinical significance of ABCC3 in glioma patients. Sequential data filtration (survival analyses, independent prognosis analyses, ROC curve analyses, and clinical association analyses) was completed, which gave rise to the determination of the relationship between glioma and the ABCC3 gene. Clinical assays on the foundation of CGGA and TCGA datasets unveiled that ABCC3 expression was distinctly upregulated in glioma and predicted a shorter overall survival. In the multivariable Cox analysis, our team discovered that the expression of ABCC3 was an independent prognosis marker for both 5-year OS (HR = 1.118, 95% CI: 1.052–1.188; P&lt;0.001). Moreover, our team also studied the association between ABCC3 expression and clinical features of glioma patients, finding that differential expression of ABCC3 was remarkably related to age, 1p19q codeletion, PRS type, chemo status, grade, IDH mutation state, and histology. 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subjects Analysis
Biomarkers
Brain tumors
Cancer
Cancer therapies
Chemotherapy
Diagnosis
Genes
Glioma
Gliomas
Medical prognosis
Metastasis
Prognosis
Survival analysis
Tumors
title Clinicopathological and Prognostic Significance of ABCC3 in Human Glioma
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