Rates of perfect self‐reported adherence to direct‐acting antiviral therapy and its correlates among people who inject drugs on medications for opioid use disorder: The PREVAIL study

Adequate adherence to direct‐acting antivirals (DAAs) for hepatitis C virus (HCV) is critical to attaining sustained virologic response (SVR). In this PREVAIL study's secondary analyses, we explored the association between self‐reported and objective DAAs adherence among a sample of people who...

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Bibliographic Details
Published in:Journal of viral hepatitis 2021-03, Vol.28 (3), p.548-557
Main Authors: Pericot‐Valverde, Irene, Rennert, Lior, Heo, Moonseong, Akiyama, Matthew J., Norton, Briana L., Agyemang, Linda, Lumsden, Brandon, Litwin, Alain H.
Format: Article
Language:English
Subjects:
Antiviral agents
Antiviral Agents - therapeutic use
Blister packs
Cocaine
direct‐acting antiviral
Drug addiction
Hepatitis C
Hepatitis C - drug therapy
hepatitis C virus
Hepatitis C, Chronic - drug therapy
Humans
Medication Adherence
medications for opioid use disorder
Narcotics
Opioid-Related Disorders
Opioids
people who inject drugs
Pharmaceutical Preparations
Self Report
self‐reported Adherence
Substance Abuse, Intravenous - drug therapy
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Summary:Adequate adherence to direct‐acting antivirals (DAAs) for hepatitis C virus (HCV) is critical to attaining sustained virologic response (SVR). In this PREVAIL study's secondary analyses, we explored the association between self‐reported and objective DAAs adherence among a sample of people who inject drugs (PWID) receiving medications for opioid use disorder (MOUD) (N = 147). Self‐reported adherence was recoded 3 times during treatment (weeks 4, 8 and 12) using a visual analog scale (VAS), whereas objective adherence was collected continuously during treatment using electronic blister packs. Participants who reported being perfectly adherent had significantly higher blister pack adherence in each period (weeks 4, 8 and 12; ps 
ISSN:1352-0504
1365-2893
DOI:10.1111/jvh.13445