RNAPhaSep: a resource of RNAs undergoing phase separation

Abstract Liquid-liquid phase separation (LLPS) partitions cellular contents, underlies the formation of membraneless organelles and plays essential biological roles. To date, most of the research on LLPS has focused on proteins, especially RNA-binding proteins. However, accumulating evidence has dem...

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Bibliographic Details
Published in:Nucleic acids research 2022-01, Vol.50 (D1), p.D340-D346
Main Authors: Zhu, Haibo, Fu, Hao, Cui, Tianyu, Ning, Lin, Shao, Huaguo, Guo, Yehan, Ke, Yanting, Zheng, Jiayi, Lin, Hongyan, Wu, Xin, Liu, Guanghao, He, Jun, Han, Xin, Li, Wenlin, Zhao, Xiaoyang, Lu, Huasong, Wang, Dong, Hu, Kongfa, Shen, Xiaopei
Format: Article
Language:English
Subjects:
Animals
Database Issue
Databases, Nucleic Acid
Eukaryotic Cells - cytology
Eukaryotic Cells - metabolism
Humans
Internet
Molecular Sequence Annotation
Organelles - chemistry
Organelles - metabolism
Phase Transition
Plants - chemistry
Plants - genetics
Plants - metabolism
RNA - chemistry
RNA - classification
RNA - genetics
RNA - metabolism
RNA-Binding Proteins - chemistry
RNA-Binding Proteins - genetics
RNA-Binding Proteins - metabolism
Saccharomyces cerevisiae - chemistry
Saccharomyces cerevisiae - genetics
Saccharomyces cerevisiae - metabolism
Software
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Summary:Abstract Liquid-liquid phase separation (LLPS) partitions cellular contents, underlies the formation of membraneless organelles and plays essential biological roles. To date, most of the research on LLPS has focused on proteins, especially RNA-binding proteins. However, accumulating evidence has demonstrated that RNAs can also function as ‘scaffolds’ and play essential roles in seeding or nucleating the formation of granules. To better utilize the knowledge dispersed in published literature, we here introduce RNAPhaSep (http://www.rnaphasep.cn), a manually curated database of RNAs undergoing LLPS. It contains 1113 entries with experimentally validated RNA self-assembly or RNA and protein co-involved phase separation events. RNAPhaSep contains various types of information, including RNA information, protein information, phase separation experiment information and integrated annotation from multiple databases. RNAPhaSep provides a valuable resource for exploring the relationship between RNA properties and phase behaviour, and may further enhance our comprehensive understanding of LLPS in cellular functions and human diseases.
ISSN:0305-1048
1362-4962
DOI:10.1093/nar/gkab985