Neutralizing antibody: a savior in the Covid-19 disease

• Published in: Molecular biology reports 2022-03, Vol.49 (3), p.2465-2474
• Main Authors: Gupta, Sneh Lata, Jaiswal, Rishi Kumar
• Format: Article
• Language: English
• Subjects: Animal Anatomy; Animal Biochemistry; Animals; Antibodies; Antibodies, Monoclonal - immunology; Antibodies, Monoclonal - therapeutic use; Antibodies, Neutralizing - blood; Antibodies, Neutralizing - immunology; Antibodies, Neutralizing - therapeutic use; Antibodies, Viral - blood; Antibodies, Viral - immunology; Antibodies, Viral - therapeutic use; Antigens, Viral - immunology; B-Lymphocytes - immunology; Biomedical and Life Sciences; Clinical Trials as Topic; Coronaviruses; COVID-19; COVID-19 - immunology; COVID-19 - therapy; Enzyme-Linked Immunosorbent Assay; Epitopes - immunology; Forecasting; Germinal Center - immunology; Histology; Humans; Immune system; Immunization, Passive; Immunogenicity; Immunoglobulin Isotypes - immunology; Immunologic Memory; Immunologic Surveillance; Immunosurveillance; Infectious diseases; Life Sciences; Macaca mulatta; Monoclonal antibodies; Morphology; Pandemics; Plasma cells; Proteins; Review; SARS-CoV-2 - genetics; SARS-CoV-2 - immunology; SARS-CoV-2 - isolation & purification; Spike Glycoprotein, Coronavirus - immunology; Spike protein; Vaccine development
• ISSN: 0301-4851; 1573-4978
• DOI: 10.1007/s11033-021-07020-6

Coronavirus outbreak was declared a pandemic by World Health Organization (WHO) in March 2020. The pandemic has led to a devastating loss of life. It has shown us how infectious diseases can cause human existence at stake, and community health is important. The spike protein is the most immunogenic component of the virus. Most vaccine development strategies have focused on the receptor-binding domain (RBD) in the spike protein because it is the most specific target site that recognizes and interacts with human lung cells. Neutralizing antibodies are generated by the humoral immune system and reduce the viral load by binding to spike protein components. Neutralizing antibodies are the proteins secreted by plasma cells and serve as an important part of the defense mechanism. In the recent Covid-19 infection, neutralizing antibodies can be utilized for both diagnostic such as immune surveillance and therapeutic tools such as plasma therapy. So far, many monoclonal antibodies are in the clinical trial phase, and few of them are already in use. In this review, we have discussed details about neutralizing antibodies and their role in combating Covid-19 disease.