Impact of booster vaccination on the control of COVID-19 Delta wave in the context of waning immunity: application to France in the winter 2021/22

Europe has experienced a large COVID-19 wave caused by the Delta variant in winter 2021/22. Using mathematical models applied to Metropolitan France, we find that boosters administered to ≥ 65, ≥ 50 or ≥ 18 year-olds may reduce the hospitalisation peak by 25%, 36% and 43% respectively, with a delay...

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Bibliographic Details
Published in:Euro surveillance : bulletin européen sur les maladies transmissibles 2022-01, Vol.27 (1)
Main Authors: Bosetti, Paolo, Tran Kiem, Cécile, Andronico, Alessio, Paireau, Juliette, Levy-Bruhl, Daniel, Alter, Lise, Fontanet, Arnaud, Cauchemez, Simon
Format: Article
Language:English
Subjects:
COVID-19
COVID-19 - prevention & control
COVID-19 vaccines
COVID-19 Vaccines - administration & dosage
Disease control
France - epidemiology
Hospitalization
Human health and pathology
Humans
Immunity (Disease)
Immunization, Secondary
Infectious diseases
Life Sciences
Mathematical models
Rapid Communication
Santé publique et épidémiologie
SARS-CoV-2
Seasons
Vaccination
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Summary:Europe has experienced a large COVID-19 wave caused by the Delta variant in winter 2021/22. Using mathematical models applied to Metropolitan France, we find that boosters administered to ≥ 65, ≥ 50 or ≥ 18 year-olds may reduce the hospitalisation peak by 25%, 36% and 43% respectively, with a delay of 5 months between second and third dose. A 10% reduction in transmission rates might further reduce it by 41%, indicating that even small increases in protective behaviours may be critical to mitigate the wave.
ISSN:1560-7917
1025-496X
1560-7917
1025-496X
DOI:10.2807/1560-7917.ES.2022.27.1.2101125