High- versus low-dose tranexamic acid as part of a Patient Blood Management strategy for reducing blood loss in patients undergoing surgery for adolescent idiopathic scoliosis

Purpose The administration of tranexamic acid (TXA) has been shown to be beneficial in reducing blood loss during surgery for adolescent idiopathic scoliosis (AIS), but optimal dosing has yet to be defined. This retrospective study compared high- versus low-dose TXA as part of a Patient Blood Manage...

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Bibliographic Details
Published in:Spine deformity 2022-01, Vol.10 (1), p.107-113
Main Authors: Tumber, Sundeep, Bacon, Adam, Stondell, Casey, Tafoya, Sampaguita, Taylor, Sandra L., Javidan, Yashar, Klineberg, Eric, Roberto, Rolando
Format: Article
Language:English
Subjects:
Adolescent
Antifibrinolytic Agents
Blood Loss, Surgical - prevention & control
Blood Transfusion
Case Series
Humans
Medicine
Medicine & Public Health
Orthopedics
Retrospective Studies
Scoliosis - surgery
Tranexamic Acid
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Summary:Purpose The administration of tranexamic acid (TXA) has been shown to be beneficial in reducing blood loss during surgery for adolescent idiopathic scoliosis (AIS), but optimal dosing has yet to be defined. This retrospective study compared high- versus low-dose TXA as part of a Patient Blood Management strategy for reducing blood loss in patients undergoing posterior spine fusion surgery. Methods Clinical records were reviewed for 223 patients with AIS who underwent posterior spinal fusion of five or more levels during a 6-year time period. We compared normalized blood loss, total estimated blood loss (EBL), and the need for transfusion between patients receiving high-dose TXA (loading dose of ≥ 30 mg/kg) versus low-dose TXA (loading dose 
ISSN:2212-134X
2212-1358
2212-1358
DOI:10.1007/s43390-021-00387-3