Defining Antibody Seroprevalence and Duration of Humoral Responses to SARS-CoV-2 Infection and/or Vaccination in a Greek Community

In this work, we aimed to evaluate antibody-response longevity to SARS-CoV-2 infection and/or vaccination in one of the Greek communities that was worst hit by the pandemic, Deskati, five months after a previous serosurveillance and nine months after the pandemic wave initiation (October 2020). The...

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Bibliographic Details
Published in:International journal of environmental research and public health 2021-12, Vol.19 (1), p.407
Main Authors: Kotsiou, Ourania S, Papagiannis, Dimitrios, Fradelos, Evangelos C, Siachpazidou, Dimitra I, Perlepe, Garifallia, Miziou, Angeliki, Kyritsis, Athanasios, Vavougios, George D, Kalantzis, Georgios, Gourgoulianis, Konstantinos I
Format: Article
Language:English
Subjects:
Adaptive immunity
Antibodies
Antibodies, Viral
Asymptomatic
Consent
Coronaviruses
COVID-19
COVID-19 vaccines
Greece - epidemiology
Herd immunity
Humans
Immune response
Immunoglobulin G
Infections
Pandemics
Population
Questionnaires
SARS-CoV-2
Seroepidemiologic Studies
Serology
Severe acute respiratory syndrome
Severe acute respiratory syndrome coronavirus 2
Vaccination
Viruses
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Summary:In this work, we aimed to evaluate antibody-response longevity to SARS-CoV-2 infection and/or vaccination in one of the Greek communities that was worst hit by the pandemic, Deskati, five months after a previous serosurveillance and nine months after the pandemic wave initiation (October 2020). The SARS-CoV-2 IgG II Quant method (Architect, Abbott, IL, USA) was used for antibody testing. A total of 69 subjects, who previously tested positive or negative for COVID-19 antibodies, participated in the study. We found that 48% of participants turned positive due to vaccination. 27% of participants were both previously infected and vaccinated. However, all previously infected participants retained antibodies to the virus, irrespective of their vaccination status. The antibody titers were significantly higher in previously infected participants that had been vaccinated than those who were unvaccinated and in those that had been previously hospitalized for COVID-19 than those with mild disease. Antibody responses to SARS-CoV-2 infection were maintained nine months after the pandemic. Vaccination alone had generated an immune response in almost half of the population. Higher antibody titers were found in the case of vaccination in previously infected subjects and especially in those with severe disease leading to hospitalization.
ISSN:1660-4601
1661-7827
1660-4601
DOI:10.3390/ijerph19010407