Exposure to Nickel Oxide Nanoparticles Induces Acute and Chronic Inflammatory Responses in Rat Lungs and Perturbs the Lung Microbiome

Nickel oxide nanoparticles (NiO NPs) are highly redox active nanoparticles. They can cause acute and chronic inflammation in rat lungs. Unlike the gut microbiome, the association between the lung microbiome's role and pulmonary inflammatory response to inhaled nanoparticles remains largely unex...

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Bibliographic Details
Published in:International journal of environmental research and public health 2022-01, Vol.19 (1), p.522
Main Authors: Jeong, Mi-Jin, Jeon, Soyeon, Yu, Hak-Sun, Cho, Wan-Seob, Lee, Seungho, Kang, Dongmug, Kim, Youngki, Kim, Yoon-Ji, Kim, Se-Yeong
Format: Article
Language:English
Subjects:
Animals
Bronchoalveolar Lavage Fluid
Bronchus
Burkholderiales
Catheters
Cytokines
Dysbacteriosis
Experiments
Exposure
Female
Gold
Inflammation
Inflammation - chemically induced
Inflammatory response
Intestinal microflora
Lavage
Leukocytes (neutrophilic)
Lung
Lungs
Metal Nanoparticles - toxicity
Microbiomes
Microbiota
Microorganisms
Nanoparticles
Nanoparticles - toxicity
Nickel
Nickel oxides
Proteins
Rats
Rats, Wistar
Rodents
Toxicology
Tumor necrosis factor-TNF
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Summary:Nickel oxide nanoparticles (NiO NPs) are highly redox active nanoparticles. They can cause acute and chronic inflammation in rat lungs. Unlike the gut microbiome, the association between the lung microbiome's role and pulmonary inflammatory response to inhaled nanoparticles remains largely unexplored. We aimed to explore the interaction between the lung microbiome and inflammatory responses in rats exposed to NiO NPs. Thirty female Wistar rats were randomly categorized into control and low- (50 cm /rat), and high- (150 cm /rat) dose NiO NPs exposure groups. NiO NPs were intratracheally instilled, and cytological, biochemical, proinflammatory cytokine, and lung microbiome analyses of bronchoalveolar lavage fluid were performed at 1 day and 4 weeks after instillation. NiO NPs caused a neutrophilic and lymphocytic inflammatory response in rat lung. We demonstrated that exposure to NiO NPs can alter the lung microbial composition in rats. In particular, we found that more are present in the NiO NPs exposure groups than in the control group at 1 day after instillation. Dysbiosis in the lung microbiome is thought to be associated with acute lung inflammation. We also suggested that may be a key biomarker associated with lung neutrophilic inflammation after NiO NPs exposure.
ISSN:1660-4601
1661-7827
1660-4601
DOI:10.3390/ijerph19010522