The Hedgehog Signaling Pathway in Idiopathic Pulmonary Fibrosis: Resurrection Time

The hedgehog (Hh) pathway is a sophisticated conserved cell signaling pathway that plays an essential role in controlling cell specification and proliferation, survival factors, and tissue patterning formation during embryonic development. Hh signal activity does not entirely disappear after develop...

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Bibliographic Details
Published in:International journal of molecular sciences 2021-12, Vol.23 (1), p.171
Main Authors: Effendi, Wiwin Is, Nagano, Tatsuya
Format: Article
Language:English
Subjects:
Abnormalities
Animals
Cell signaling
Cholesterol
Embryogenesis
Fibrosis
Gene expression
Hedgehog protein
Hedgehog Proteins - metabolism
Homeostasis
Humans
Idiopathic Pulmonary Fibrosis - metabolism
Kinases
Ligands
Lipids
Localization
Lung diseases
Microenvironments
Morphogenesis
Pattern formation
Proteins
Pulmonary fibrosis
Review
Signal Transduction
Transcription factors
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Summary:The hedgehog (Hh) pathway is a sophisticated conserved cell signaling pathway that plays an essential role in controlling cell specification and proliferation, survival factors, and tissue patterning formation during embryonic development. Hh signal activity does not entirely disappear after development and may be reactivated in adulthood within tissue-injury-associated diseases, including idiopathic pulmonary fibrosis (IPF). The dysregulation of Hh-associated activating transcription factors, genomic abnormalities, and microenvironments is a co-factor that induces the initiation and progression of IPF.
ISSN:1422-0067
1661-6596
1422-0067
DOI:10.3390/ijms23010171