Sex Hormone Receptor Expression in Craniopharyngiomas and Association with Tumor Aggressiveness Characteristics

Craniopharyngiomas (CPs) are rare tumors of the sellar and suprasellar regions of embryonic origin. The primary treatment for CPs is surgery but it is often unsuccessful. Although CPs are considered benign tumors, they display a relatively high recurrence rate that might compromise quality of life....

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Published in:Journal of clinical medicine 2022-01, Vol.11 (1), p.281
Main Authors: Martínez-Ortega, Antonio, Flores-Martinez, Álvaro, Venegas-Moreno, Eva, Dios, Elena, Del Can, Diego, Rivas, Eloy, Kaen, Ariel, Cárdenas Ruiz-Valdepeñas, Eugenio, Fajardo, Elena, Roldán, Florinda, González-Rivera, Natividad, Oliva, Rosario, Fernández-Peña, José Ignacio, Soto-Moreno, Alfonso, Cano, David A
Format: Article
Language:English
Subjects:
Brain cancer
Clinical medicine
Estrogens
Localization
Medical imaging
Medical prognosis
Mutation
Statistical analysis
Surgery
Tumors
Values
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Summary:Craniopharyngiomas (CPs) are rare tumors of the sellar and suprasellar regions of embryonic origin. The primary treatment for CPs is surgery but it is often unsuccessful. Although CPs are considered benign tumors, they display a relatively high recurrence rate that might compromise quality of life. Previous studies have reported that CPs express sex hormone receptors, including estrogen and progesterone receptors. Here, we systematically analyzed estrogen receptor α (ERα) and progesterone receptor (PR) expression by immunohistochemistry in a well-characterized series of patients with CP ( = 41) and analyzed their potential association with tumor aggressiveness features. A substantial proportion of CPs displayed a marked expression of PR. However, most CPs expressed low levels of ERα. No major association between PR and ERα expression and clinical aggressiveness features was observed in CPs. Additionally, in our series, β-catenin accumulation was not related to tumor recurrence.
ISSN:2077-0383
2077-0383
DOI:10.3390/jcm11010281