Implication of Ceramide Kinase/C1P in Cancer Development and Progression

Cancer cells rewire their metabolic programs to favor biological processes that promote cell survival, proliferation, and dissemination. Among this relevant reprogramming, sphingolipid metabolism provides metabolites that can favor or oppose these hallmarks of cancer. The sphingolipid ceramide 1-pho...

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Bibliographic Details
Published in:Cancers 2022-01, Vol.14 (1), p.227
Main Authors: Camacho, Laura, Ouro, Alberto, Gomez-Larrauri, Ana, Carracedo, Arkaitz, Gomez-Muñoz, Antonio
Format: Article
Language:English
Subjects:
Apoptosis
Binding sites
Bone marrow
Breast cancer
Cancer therapies
Cell adhesion & migration
Cell division
Cell growth
Cell migration
Cell survival
Ceramide
Ceramide kinase
Embryos
Enzymes
Fibroblasts
Gene expression
Inflammation
Intracellular
Kinases
Leukemia
Lipid metabolism
Lung cancer
Metastases
Mortality
Ovaries
Pancreas
Pancreatic cancer
Phosphorylation
Physiology
Prostate
Proteins
Review
Second messengers
Sphingolipid ceramide
Sphingolipids
Stem cells
Tumorigenesis
Vascular endothelial growth factor
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Summary:Cancer cells rewire their metabolic programs to favor biological processes that promote cell survival, proliferation, and dissemination. Among this relevant reprogramming, sphingolipid metabolism provides metabolites that can favor or oppose these hallmarks of cancer. The sphingolipid ceramide 1-phosphate (C1P) and the enzyme responsible for its biosynthesis, ceramide kinase (CERK), are well established regulators of cell growth and survival in normal, as well as malignant cells through stress-regulated signaling pathways. This metabolite also promotes cell survival, which has been associated with the feedback regulation of other antitumoral sphingolipids or second messengers. C1P also regulates cancer cell invasion and migration of different types of cancer, including lung, breast, pancreas, prostate, or leukemia cells. More recently, CERK and C1P have been implicated in the control of inflammatory responses. The present review provides an updated view on the important role of CERK/C1P in the regulation of cancer cell growth, survival, and dissemination.
ISSN:2072-6694
2072-6694
DOI:10.3390/cancers14010227