Outcomes after Surgical Treatment of Metastatic Disease in the Adrenal Gland; Valuable for the Patient?

The adrenal glands are common dissemination sites for metastasis of various solid tumors. Surgical treatment is often recommended because targeted therapies and immunotherapy are frequently ineffective for adrenal metastasis. We report the experience with short-term and long-term surgical outcomes o...

Full description

Saved in:
Bibliographic Details
Published in:Cancers 2021-12, Vol.14 (1), p.156
Main Authors: Metman, Madelon J H, Viëtor, Charlotte L, Seinen, Auke J, Berends, Annika M A, Hemmer, Patrick H J, Kerstens, Michiel N, Feelders, Richard A, Franssen, Gaston J H, van Ginhoven, Tessa M, Kruijff, Schelto
Format: Article
Language:English
Subjects:
Adrenal glands
Adrenalectomy
Breast cancer
Colorectal cancer
Complications
Hospitals
Immunotherapy
Invasiveness
Laparoscopy
Liver
Lung cancer
Medical records
Melanoma
Metastases
Metastasis
Morbidity
Patients
Postoperative
Solid tumors
Surgery
Surgical outcomes
Surgical techniques
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:The adrenal glands are common dissemination sites for metastasis of various solid tumors. Surgical treatment is often recommended because targeted therapies and immunotherapy are frequently ineffective for adrenal metastasis. We report the experience with short-term and long-term surgical outcomes of patients undergoing surgery for adrenal metastasis in two hospitals. A retrospective, multicenter study was performed to analyze patient characteristics, tumor-related data, perioperative outcomes, and oncological outcomes. Postoperative complications that occurred within 30 days were scored according to the Clavien Dindo classification. Metastatic adrenalectomy was performed in 95 patients. We observed an increase from an average of 3 metastatic adrenalectomies per year between 2001-2005 to 10 between 2015-2019. The most frequent underlying malignancies were colorectal and lung cancer. In 55.8%, minimal invasive adrenalectomy was performed, including six conversions to open surgery. A total of 37.9% of patients had postoperative complications, of which ileus or gastroparesis, wound problems, pneumonia, and heart arrhythmias were the most occurring complications. Improved cancer care has led to an increased demand for metastatic adrenalectomy over the past years. Complication rates of 37.9% are significant and cannot be neglected. Therefore, multidisciplinary teams should weigh the decision to perform metastatic adrenalectomy for each patient individually, taking into account the drawbacks of the described morbidity versus the potential benefits.
ISSN:2072-6694
2072-6694
DOI:10.3390/cancers14010156