Lymph Node Involvement in Early-Stage Cervical Cancer: Is Lymphangiogenesis a Risk Factor? Results from the MICROCOL Study

In patients with cervical cancer, the presence of tumoral lymph-vascular space invasion (LVSI) is the main risk factor for pelvic lymph node metastasis (PLNM). The objective of this study was to evaluate the presence of several markers of lymphangiogenesis in early-stage cervical cancer and their co...

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Bibliographic Details
Published in:Cancers 2022-01, Vol.14 (1), p.212
Main Authors: Tantari, Matteo, Bogliolo, Stefano, Morotti, Matteo, Balaya, Vincent, Bouttitie, Florent, Buenerd, Annie, Magaud, Laurent, Lecuru, Fabrice, Guani, Benedetta, Mathevet, Patrice, On Behalf Of The Senticol Group
Format: Article
Language:English
Subjects:
Angiogenesis
Cancer therapies
Cell growth
Cell proliferation
Cervical cancer
Cervical carcinoma
Chemotherapy
Endothelial cells
Laboratories
Lymph nodes
Lymphatic system
Medical prognosis
Metastases
Metastasis
Risk factors
Statistical analysis
Tumors
Vascular endothelial growth factor
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Summary:In patients with cervical cancer, the presence of tumoral lymph-vascular space invasion (LVSI) is the main risk factor for pelvic lymph node metastasis (PLNM). The objective of this study was to evaluate the presence of several markers of lymphangiogenesis in early-stage cervical cancer and their correlation with PLNM and tumoral recurrence. Seventy-five patients with early-stage cervical carcinoma underwent sentinel lymph node (SLN) sampling in association with complete pelvic lymph node dissection. Primary tumors were stained with the following markers: Ki67, D2-40, CD31 and VEGF-C. A 3-year follow-up was performed to evaluate the disease-free survival. Overall, 14 patients (18.6%) had PLNM. Positive LVSI was seen in 29 patients (38.6%). There was a significant correlation between LVSI evidenced by H/E staining and PLNM ( < 0.001). There was no correlation between high Ki67, CD31, D2-40, and VEGF-C staining with PLNM or tumor recurrence. Our data support that lymphatic spread does not require the proliferation of new lymphatic endothelial cells in early-stage cervical cancer. These results emphasize the importance of pre-existing peritumoral lymphatic vessels in the metastatic process in early cervical cancer. None of the markers of lymphangiogenesis and proliferation assessed in this study were predictive of PLNM or recurrence.
ISSN:2072-6694
2072-6694
DOI:10.3390/cancers14010212