Recurrence or reactivation of SARS-CoV-2 infection after immunosuppressive therapy in patients with ANCA-associated vasculitis and COVID-19

. Acute tubular injury is the lesion most frequently described in this disease. However, four cases of ANCA-associated vasculitis (AAV) with COVID-19 with pauci-immune glomerulonephritis have recently been described. We report the case of an African woman, aged 70, in whom we diagnosed an AAV with p...

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Bibliographic Details
Published in:Clinical nephrology. Case studies 2022, Vol.10 (2196-5293), p.6-10
Main Authors: Mbengue, Mansour, Bigirimana, Bede, Irankunda, Lolly Romeo, Dial, Mohamed Cherif, Niang, Abdou
Format: Article
Language:English
Subjects:
Antigens
Case Report
Case studies
COVID-19
Creatinine
Hematuria
Infections
Kidneys
Medical imaging
Nephrology
Patients
Severe acute respiratory syndrome coronavirus 2
Viral infections
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Summary:. Acute tubular injury is the lesion most frequently described in this disease. However, four cases of ANCA-associated vasculitis (AAV) with COVID-19 with pauci-immune glomerulonephritis have recently been described. We report the case of an African woman, aged 70, in whom we diagnosed an AAV with pauci-immune glomerulonephritis in the context of COVID-19. She was treated with hydroxychloroquine and azithromycin for COVID-19. Corticosteroids and cyclophosphamide have been used for the treatment of vasculitis. The evolution was marked by the reappearance of COVID-19 one month after the beginning of an immunosuppressive therapy. The patient died a week later from respiratory failure. The occurrence of AAV during COVID-19 may not be due an unfortunate association but triggered by infection with SARS-CoV-2. The use of immunosuppressive therapy should be discussed due to the potential risk of reactivation or recurrence of the viral infection.
ISSN:2196-5293
2196-5293
DOI:10.5414/CNCS110567