Long-Term (7-Year) Clinical Implications of Newly Unveiled Asymptomatic Abnormal Ankle-Brachial Index in Patients With Coronary Artery Disease

• Published in: Journal of the American Heart Association 2021-10, Vol.10 (20), p.e021587-e021587
• Main Authors: Lee, Jong-Young, Lee, Seung-Jae, Lee, Seung-Whan, Kim, Tae Oh, Yang, Yujin, Jeong, Yeong Jin, Park, Hanbit, Lee, Junghoon, Hyun, Junho, Kim, Ju Hyeon, Lee, Pil Hyung, Kang, Soo-Jin, Kim, Young-Hak, Lee, Cheol Whan, Park, Seong-Wook
• Format: Article
• Language: English
• Subjects: Ankle Brachial Index; Cause of Death; Coronary Artery Disease - epidemiology; Coronary Artery Disease - physiopathology; Follow-Up Studies; Humans; Myocardial Infarction - epidemiology; Original Research; Predictive Value of Tests; Risk Factors; Stroke - epidemiology
• ISSN: 2047-9980; 2047-9980
• DOI: 10.1161/JAHA.121.021587

Background The long-term impact of newly discovered, asymptomatic abnormal ankle-brachial index (ABI) in patients with significant coronary artery disease is limited. Methods and Results Between January 2006 and December 2009, ABI was evaluated in 2424 consecutive patients with no history of claudication or peripheral artery disease who had significant coronary artery disease. We previously reported a 3-year result; therefore, the follow-up period was extended. The primary end point was a composite of all-cause death, myocardial infarction (MI), and stroke over 7 years. Of the 2424 patients with significant coronary artery disease, 385 had an abnormal ABI (ABI ≤0.9 or ≥1.4). During the follow-up period, the rate of the primary outcome was significantly higher in the abnormal ABI group than in the normal ABI group (