The role of CD36 in cardiovascular disease

Abstract CD36, also known as the scavenger receptor B2, is a multifunctional receptor widely expressed in various organs. CD36 plays a crucial role in the uptake of long-chain fatty acids, the main metabolic substrate in myocardial tissue. The maturation and transportation of CD36 is regulated by po...

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Bibliographic Details
Published in:Cardiovascular research 2022-01, Vol.118 (1), p.115-129
Main Authors: Shu, Hongyang, Peng, Yizhong, Hang, Weijian, Nie, Jiali, Zhou, Ning, Wang, Dao Wen
Format: Article
Language:English
Subjects:
Animals
Cardiovascular Diseases - genetics
Cardiovascular Diseases - metabolism
Cardiovascular Diseases - pathology
Cardiovascular Diseases - physiopathology
CD36 Antigens - genetics
CD36 Antigens - metabolism
Genetic Predisposition to Disease
Humans
Myocytes, Cardiac - metabolism
Myocytes, Cardiac - pathology
Polymorphism, Genetic
Protein Processing, Post-Translational
Reviews
Signal Transduction
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Summary:Abstract CD36, also known as the scavenger receptor B2, is a multifunctional receptor widely expressed in various organs. CD36 plays a crucial role in the uptake of long-chain fatty acids, the main metabolic substrate in myocardial tissue. The maturation and transportation of CD36 is regulated by post-translational modifications, including phosphorylation, ubiquitination, glycosylation, and palmitoylation. CD36 is decreased in pathological cardiac hypertrophy caused by ischaemia–reperfusion and pressure overload, and increased in diabetic cardiomyopathy and atherosclerosis. Deficiency of CD36 alleviates diabetic cardiomyopathy and atherosclerosis, while overexpression of CD36 eliminates ischaemia–reperfusion damage, together suggesting that CD36 is closely associated with the progression of cardiovascular diseases and may be a new therapeutic target. This review summarizes the regulation and post-translational modifications of CD36 and evaluates its role in cardiovascular diseases and its potential as a therapeutic target.
ISSN:0008-6363
1755-3245
DOI:10.1093/cvr/cvaa319