IFNγ signaling integrity in colorectal cancer immunity and immunotherapy

The majority of colorectal cancer patients are not responsive to immune checkpoint blockade (ICB). The interferon gamma (IFNγ) signaling pathway drives spontaneous and ICB-induced antitumor immunity. In this review, we summarize recent advances in the epigenetic, genetic, and functional integrity of...

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Bibliographic Details
Published in:Cellular & molecular immunology 2022-01, Vol.19 (1), p.23-32
Main Authors: Du, Wan, Frankel, Timothy L., Green, Michael, Zou, Weiping
Format: Article
Language:English
Subjects:
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Antibodies
Apoptosis
Biomedical and Life Sciences
Biomedicine
Cancer
Clinical trials
Colorectal cancer
Colorectal carcinoma
Colorectal Neoplasms - genetics
Colorectal Neoplasms - therapy
Epigenetics
Ferroptosis
Humans
Immune checkpoint
Immunology
Immunotherapy
Interferon-gamma - metabolism
Medical Microbiology
Microbiology
Microenvironments
Patients
Protein Transport
Review
Review Article
Signal Transduction
Tumor Microenvironment
Vaccine
γ-Interferon
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Description
Summary:The majority of colorectal cancer patients are not responsive to immune checkpoint blockade (ICB). The interferon gamma (IFNγ) signaling pathway drives spontaneous and ICB-induced antitumor immunity. In this review, we summarize recent advances in the epigenetic, genetic, and functional integrity of the IFNγ signaling pathway in the colorectal cancer microenvironment and its immunological relevance in the therapeutic efficacy of and resistance to ICB. Moreover, we discuss how to target IFNγ signaling to inform novel clinical trials to treat patients with colorectal cancer.
ISSN:1672-7681
2042-0226
2042-0226
DOI:10.1038/s41423-021-00735-3