Contributions of microRNAs to Peripheral Insulin Sensitivity

An extensive literature base combined with advances in sequencing technologies demonstrate microRNA levels correlate with various metabolic diseases. Mechanistic studies also establish microRNAs regulate central metabolic pathways and thus play vital roles in maintaining organismal energy balance an...

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Bibliographic Details
Published in:Endocrinology (Philadelphia) 2022-02, Vol.163 (2), p.1
Main Authors: Kim, Kang Ho, Hartig, Sean M
Format: Article
Language:English
Subjects:
Adipose Tissue
Animal models
Animals
Carbohydrate metabolism
Carbohydrates
Development and progression
Dextrose
Endocrinology
Energy balance
Energy Metabolism - genetics
Gene Expression Regulation
Glucose
Glucose - metabolism
Homeostasis
Humans
Insulin
Insulin Resistance - genetics
Lipid metabolism
Lipid Metabolism - genetics
Lipids
Medical research
Medicine, Experimental
Metabolic Diseases - genetics
Metabolic disorders
Metabolic pathways
MicroRNA
MicroRNAs - physiology
Mini-Review
miRNA
Protein binding
Proteins
Ribonucleic acid
RNA
Sensitivity
Type 2 diabetes
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Summary:An extensive literature base combined with advances in sequencing technologies demonstrate microRNA levels correlate with various metabolic diseases. Mechanistic studies also establish microRNAs regulate central metabolic pathways and thus play vital roles in maintaining organismal energy balance and metabolic homeostasis. This review highlights research progress on the roles and regulation of microRNAs in the peripheral tissues that confer insulin sensitivity. We discuss sequencing technologies used to comprehensively define the target spectrum of microRNAs in metabolic disease that complement studies reporting physiologic roles for microRNAs in the regulation of glucose and lipid metabolism in animal models. We also discuss the emerging roles of exosomal microRNAs as endocrine signals to regulate lipid and carbohydrate metabolism.
ISSN:0013-7227
1945-7170
DOI:10.1210/endocr/bqab250