Potential Inhibitors Targeting Escherichia coli UDP-N-Acetylglucosamine Enolpyruvyl Transferase (MurA): An Overview

Antibiotic resistance is one of the biggest challenges that is escalating and affecting humanity across the globe. To overcome this increasing burden of resistance, discovering novel hits by targeting the enzymes involved in peptidoglycan (murein) biosynthesis has always been considered better in an...

Full description

Saved in:
Bibliographic Details
Published in:Indian journal of microbiology 2022-03, Vol.62 (1), p.11-22
Main Authors: Raina, Diksha, Kumar, Chetan, Kumar, Vinod, Khan, Inshad Ali, Saran, Saurabh
Format: Article
Language:English
Subjects:
Antibiotic resistance
Antibiotics
Antiinfectives and antibacterials
Antimicrobial agents
Biomedical and Life Sciences
Biosynthesis
Cell walls
Chemical synthesis
Clinical trials
E coli
Enzymes
Escherichia coli
Inhibitors
Life Sciences
Medical Microbiology
Microbiology
N-Acetylglucosamine
Penicillin
Peptidoglycans
Review
Review Article
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:Antibiotic resistance is one of the biggest challenges that is escalating and affecting humanity across the globe. To overcome this increasing burden of resistance, discovering novel hits by targeting the enzymes involved in peptidoglycan (murein) biosynthesis has always been considered better in antimicrobial drug discovery. UDP-N-acetylglucosamine enolpyruvyl transferase (MurA) enzyme has been identified as essential for Escherichia coli survival and catalyzes the early-stage step in bacterial cell wall synthesis. The present article gives a brief overview of the role of enzymes in peptidoglycan synthesis and MurA enzyme (previously known as MurZ in E. coli ), in particular, including its structural and active site features. This review also provides an insight into the current knowledge of the reported MurA inhibitors, their mechanism of action and drawbacks of these hits that hinder their clinical trials, which would be helpful for synthesis and discovering potent molecules.
ISSN:0046-8991
0973-7715
DOI:10.1007/s12088-021-00988-6