Guide RNA acrobatics: the one-for-two shuffle

RNA modifications are crucial for the proper function of the RNAs. The sites of pseudouridines are often specified by dual hairpin guide RNAs, with one or both hairpins identifying a target uridine. In this issue of , Jády and colleagues (pp. 70-83) identify a novel mechanism by which a single guide...

Full description

Saved in:
Bibliographic Details
Published in:Genes & development 2022-01, Vol.36 (1-2), p.1-3
Main Author: Meier, U Thomas
Format: Article
Language:English
Subjects:
Outlook
Pseudouridine - genetics
Pseudouridine - metabolism
RNA - genetics
RNA - metabolism
RNA Processing, Post-Transcriptional
RNA, Guide, CRISPR-Cas Systems
RNA, Ribosomal - genetics
RNA, Small Nucleolar
Citations: Items that this one cites
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:RNA modifications are crucial for the proper function of the RNAs. The sites of pseudouridines are often specified by dual hairpin guide RNAs, with one or both hairpins identifying a target uridine. In this issue of , Jády and colleagues (pp. 70-83) identify a novel mechanism by which a single guide RNA hairpin can specify two uridines adjacent to each other or separated by 1 nt; i.e., one for two or guide RNA acrobatics.
ISSN:0890-9369
1549-5477
1549-5477
DOI:10.1101/gad.349285.121