Colonic Metastasis from Breast Cancer: A Case Report and Review of the Literature

• Published in: In vivo (Athens) 2022-01, Vol.36 (1), p.522-527
• Main Authors: Inoue, Hiroyuki, Arita, Tomohiro, Kuriu, Yoshiaki, Shimizu, Hiroki, Kiuchi, Jun, Yamamoto, Yusuke, Konishi, Hirotaka, Morimura, Ryo, Shiozaki, Atsushi, Ikoma, Hisashi, Kubota, Takeshi, Fujiwara, Hitoshi, Okamoto, Kazuma, Otsuji, Eigo
• Format: Article
• Language: English
• Subjects: Breast Neoplasms - surgery; Colon, Sigmoid; Female; Humans; Mastectomy; Middle Aged; Neoplasm Recurrence, Local; Sigmoid Neoplasms - surgery
• ISSN: 0258-851X; 1791-7549
• DOI: 10.21873/invivo.12733

Breast cancer often metastasizes to the lungs, bones, liver, and brain, colon metastasis from breast cancer (CMBC) is extremely rare. The patient was a 63-year-old female. Mastectomy had been performed for breast cancer (pStage IIB) 15 years earlier at another hospital. Metastasis to the lumbar spine had been detected 4 years prior to referral to us and the patient had undergone hormonal therapy with an aromatase inhibitor. Furthermore, early primary sigmoid colon cancer had been endoscopically resected 2 years before referral. The patient was diagnosed with cancer recurrence in the colon at follow-up examinations performed 2 years after that endoscopic resection. After referral to our hospital, laparoscopic sigmoidectomy was performed. Based on the histopathological examination and immunohistological staining results (positive for cytokeratin 7, GATA-binding protein 3, estrogen receptor and human epidermal growth factor receptor-related 2 (2+); negative for cytokeratin 20, progesterone receptor, E-cadherin, gross cystic disease fluid protein 15 and caudal-related homeobox 2) the final pathological diagnosis was CMBC. Although extremely rare, the possibility of CMBC should be considered in the case of colonic tumors in patients with a history of breast cancer.