Alpha-Fetoprotein Ratio Predicts Alpha-Fetoprotein Positive Hepatocellular Cancer Patient Prognosis after Hepatectomy

Background. This study was conducted to investigate the effect of alpha-fetoprotein (AFP) ratio on the prognosis of AFP-positive hepatocellular carcinoma (HCC) patients after hepatectomy. Methods. We retrospectively included 879 HCC patients with AFP-positive who underwent hepatectomy from February...

Full description

Saved in:
Bibliographic Details
Published in:Disease markers 2022, Vol.2022, p.7640560-9
Main Authors: Sun, Li-Yue, Cen, Wen-Jian, Tang, Wen-Ting, Deng, Ling, Wang, Fang, Ji, Xiao-Meng, Yang, Jiao-Jiao, Zhang, Ren-Jing, Zhang, Xu-Hui, Du, Zi-Ming
Format: Article
Language:English
Subjects:
alpha-Fetoproteins - analysis
Cancer
Carcinoma, Hepatocellular - pathology
Hepatectomy
Hepatocellular carcinoma
Humans
Liver cancer
Liver Neoplasms - pathology
Magnetic resonance imaging
Medical prognosis
Metastasis
Multivariate analysis
Patients
Prognosis
Retrospective Studies
Risk analysis
Risk factors
Software
Statistical analysis
Surgery
Survival
Survival Rate
Training
Variance analysis
α-Fetoprotein
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:Background. This study was conducted to investigate the effect of alpha-fetoprotein (AFP) ratio on the prognosis of AFP-positive hepatocellular carcinoma (HCC) patients after hepatectomy. Methods. We retrospectively included 879 HCC patients with AFP-positive who underwent hepatectomy from February 2012 to October 2017 and randomly divided into training cohort and validation cohort. AFP ratio was equal to the AFP level within one week before hepatectomy to AFP level within 20-40 days after surgery. The end point of follow-up was disease-free survival (DFS) and overall survival (OS). Results. AFP ratio was not associated with clinical characteristics in training cohort and validation cohort. According to the X-tile software, the optimum cut-off point was 17.8 for AFP ratio. Significant differences between AFP ratio high and AFP ratio low were observed in DFS and OS in both cohort (p
ISSN:0278-0240
1875-8630
DOI:10.1155/2022/7640560