Kupffer Cell Hyaline Globules in Children With Autoimmune Hepatitis

Hyaline globules (HGs) in the cytoplasm of Kupffer cells (KCs) have been appraised for being a typical feature of autoimmune hepatitis (AIH). This study aimed to determine how useful Kupffer cell hyaline globules (KCHGs) are in diagnosing AIH vs. other causes of pediatric chronic liver diseases (PCL...

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Bibliographic Details
Published in:Journal of clinical and experimental hepatology 2022-01, Vol.12 (1), p.20-28
Main Authors: Khedr, Mohammed A., Adawy, Nermin M., Salim, Tahany A., Salem, Menan E., Ghazy, Ramy M., Elharoun, Ahmed S., Sultan, Mervat M., Ehsan, Nermine A.
Format: Article
Language:English
Subjects:
autoimmune hepatitis
hepatitis C virus infection
hyaline globules
Kupffer cells
liver histopathology
Original
Wilson’s disease
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Summary:Hyaline globules (HGs) in the cytoplasm of Kupffer cells (KCs) have been appraised for being a typical feature of autoimmune hepatitis (AIH). This study aimed to determine how useful Kupffer cell hyaline globules (KCHGs) are in diagnosing AIH vs. other causes of pediatric chronic liver diseases (PCLDs). This retrospective study recruited 124 children; 58 with AIH, 50 with chronic hepatitis C virus (HCV) infection, and 16 with Wilson’s disease (WD). Two pathologists retrieved paraffin blocks of liver biopsies and prepared new cut sections for Periodic acid–Schiff–Diastase (PAS-D) stain. They independently examined liver biopsies before starting treatment. Two pediatricians reviewed medical records for demographic, clinical, laboratory, and serological findings. Females represented 48.6% of the studied children with a median age of 5.8 (4.9) years. Pathologists identified KCHGs in 67.24%, 12.5%, and 6.0% of AIH, WD, and HCV affected children respectively, P 
ISSN:0973-6883
2213-3453
DOI:10.1016/j.jceh.2021.04.013