Assessing the Potential Value and Mechanism of Kaji-Ichigoside F1 on Arsenite-Induced Skin Cell Senescence

Chronic exposure to inorganic arsenic is a major environmental public health issue worldwide affecting more than 220 million of people. Previous studies have shown the correlation between arsenic poisoning and cellular senescence; however, knowledge regarding the mechanism and effective prevention m...

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Published in:Oxidative medicine and cellular longevity 2022, Vol.2022, p.9574473-16
Main Authors: Zeng, Qibing, Du, Sufei, Xu, Yuyan, Yang, Fan, Wu, Liping, Wang, Nanlan, Zhang, Shuling, Wei, Shaofeng, Wang, Guoze, Zhang, Shuai, Lu, Hongguang, Luo, Peng
Format: Article
Language:English
Subjects:
Arsenic
Arsenites - adverse effects
Cell culture
Cell cycle
Cellular Senescence - drug effects
Chronic illnesses
Cytokines
Disease prevention
Drugs, Chinese Herbal - pharmacology
Drugs, Chinese Herbal - therapeutic use
Enzymes
Epidermal growth factor
Herbal medicine
Humans
Ingredients
Kinases
Oxidative stress
Poisoning
Proteins
Senescence
Skin - drug effects
Transcription factors
Vascular endothelial growth factor
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Summary:Chronic exposure to inorganic arsenic is a major environmental public health issue worldwide affecting more than 220 million of people. Previous studies have shown the correlation between arsenic poisoning and cellular senescence; however, knowledge regarding the mechanism and effective prevention measures has not been fully studied. First, the associations among the ERK/CEBPB signaling pathway, oxidative stress, and arsenic-induced skin cell senescence were confirmed using the HaCaT cell model. In the arsenic-exposed group, the relative mRNA and protein expressions of ERK/CEBPB signaling pathway indicators (ERK1, ERK2, and CEBPB), cell cycle-related genes (p21, p16INK4a), and the secretion of SASP (IL-1α, IL-6, IL-8, TGF-β1, MMP-1, MMP-3, EGF, and VEGF) and the lipid peroxidation product (MDA) were significantly increased in cells (P
ISSN:1942-0900
1942-0994
DOI:10.1155/2022/9574473