Prognostic impact of toll-like receptors gene polymorphism on outcome of COVID-19 pneumonia: A case-control study

Toll-like receptor 3 (TLR3) and TLR7 genes are involved in the host immune response against viral infections including SARS-COV-2. This study aimed to investigate the association between the TLR3(rs3775290) and TLR7(rs179008) polymorphisms with the prognosis and susceptibility to COVID-19 pneumonia...

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Published in:Clinical immunology (Orlando, Fla.) Fla.), 2022-02, Vol.235, p.108929-108929, Article 108929
Main Authors: Alseoudy, Mahmoud M., Elgamal, Mohamed, Abdelghany, Dalia A., Borg, Asmaa M., El-Mesery, Ahmed, Elzeiny, Dina, Hammad, Maha O.
Format: Article
Language:English
Subjects:
Aged
Alleles
Case-Control Studies
COVID-19 - diagnosis
COVID-19 - genetics
COVID-19 - virology
COVID-19 pneumonia
Female
Gene Frequency
Gene polymophism
Genetic Predisposition to Disease - genetics
Genotype
Humans
Male
Middle Aged
Pneumonia - diagnosis
Pneumonia - genetics
Pneumonia - virology
Polymorphism, Single Nucleotide
Prognosis
Real time PCR
Risk Factors
ROC Curve
SARS-CoV-2 - physiology
Toll-Like Receptor 3 - genetics
Toll-Like Receptor 7 - genetics
Toll-like receptors
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Summary:Toll-like receptor 3 (TLR3) and TLR7 genes are involved in the host immune response against viral infections including SARS-COV-2. This study aimed to investigate the association between the TLR3(rs3775290) and TLR7(rs179008) polymorphisms with the prognosis and susceptibility to COVID-19 pneumonia accompanying SARS-COV-2 infection. This case-control study included 236 individuals: 136 COVID-19 pneumonia patients and 100 age and sex-matched controls. Two polymorphisms (TLR3 rs3775290 and TLR7 rs179008) were genotyped by allelic discrimination through TaqMan real-time PCR. This study also investigated predictors of mortality in COVID-19 pneumonia through logistic regression. The mutant ‘T/T' genotypes and the ‘T' alleles of TLR3(rs3775290) and TLR7(rs179008) polymorphisms were significantly associated with increased risk of COVID-19 pneumonia. This study did not report association between the mutant ‘T/T' genotypes of TLR3(rs3775290) and TLR7(rs179008) and the disease outcome. In multivariate analysis, the independent predictors of mortality in COVID-19 pneumonia were male sex, SPO2 ≤ 82%, INR > 1, LDH ≥ 1000 U/l, and lymphocyte count
ISSN:1521-6616
1521-7035
DOI:10.1016/j.clim.2022.108929