Exposure to chemical components of fine particulate matter and ozone, and placenta-mediated pregnancy complications in Tokyo: a register-based study

• Published in: Journal of exposure science & environmental epidemiology 2022-01, Vol.32 (1), p.135-145
• Main Authors: Michikawa, Takehiro, Morokuma, Seiichi, Yamazaki, Shin, Takami, Akinori, Sugata, Seiji, Yoshino, Ayako, Takeda, Yuki, Nakahara, Kazushige, Saito, Shinji, Hoshi, Junya, Kato, Kiyoko, Nitta, Hiroshi, Nishiwaki, Yuji
• Format: Article
• Language: English
• Subjects: Air Pollutants - analysis; Air Pollutants - toxicity; Air Pollution - analysis; Air Pollution - statistics & numerical data; Carbon; Epidemiology; Exposure; Female; Humans; Maternal Exposure - adverse effects; Medicine; Medicine & Public Health; Organic carbon; Ozone; Ozone - analysis; Ozone - toxicity; Particulate matter; Particulate Matter - analysis; Particulate Matter - toxicity; Placenta; Placenta - chemistry; Pollutants; Pre-eclampsia; Pregnancy; Pregnancy complications; Pregnancy Complications - chemically induced; Small for gestational age; Tokyo - epidemiology
• ISSN: 1559-0631; 1559-064X
• DOI: 10.1038/s41370-021-00299-4

Background Maternal exposure to fine particulate matter (PM 2.5 ) was associated with pregnancy complications. However, we still lack comprehensive evidence regarding which specific chemical components of PM 2.5 are more harmful for maternal and foetal health. Objective We focused on exposure over the first trimester (0–13 weeks of gestation), which includes the early placentation period, and investigated whether PM 2.5 and its components were associated with placenta-mediated pregnancy complications (combined outcome of small for gestational age, preeclampsia, placental abruption, and stillbirth). Methods From 2013 to 2015, we obtained information, from the Japan Perinatal Registry Network database, on 83,454 women who delivered singleton infants within 23 Tokyo wards (≈627 km 2 ). Using daily filter sampling of PM 2.5 at one monitoring location, we analysed carbon and ion components, and assigned the first trimester average of the respective pollutant concentrations to each woman. Results The ORs of placenta-mediated pregnancy complications were 1.14 (95% CI = 1.08–1.22) per 0.51 μg/m 3 (interquartile range) increase of organic carbon and 1.11 (1.03–1.18) per 0.06 μg/m 3 increase of sodium. Organic carbon was also associated with four individual complications. There was no association between ozone and outcome. Significance There were specific components of PM 2.5 that have adverse effects on maternal and foetal health.