Myeloid Cell-Derived Oxidized Lipids and Regulation of the Tumor Microenvironment

Immunosuppressive myeloid cells play a major role in cancer by negatively regulating immune responses, promoting tumor progression, and limiting the efficacy of cancer immunotherapy. Immunosuppression is mediated by various mechanisms dependent upon the type of myeloid cell involved. In recent years...

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Bibliographic Details
Published in:Cancer research (Chicago, Ill.) Ill.), 2022-01, Vol.82 (2), p.187-194
Main Authors: Hicks, Kristin C, Tyurina, Yulia Y, Kagan, Valerian E, Gabrilovich, Dmitry I
Format: Article
Language:English
Subjects:
Animals
Humans
Immune Tolerance
Lipid Metabolism - immunology
Myeloid Cells - immunology
Myeloid Cells - metabolism
Neoplasms - immunology
Neoplasms - metabolism
Neoplasms - pathology
Oxidation-Reduction
Tumor Microenvironment - immunology
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Summary:Immunosuppressive myeloid cells play a major role in cancer by negatively regulating immune responses, promoting tumor progression, and limiting the efficacy of cancer immunotherapy. Immunosuppression is mediated by various mechanisms dependent upon the type of myeloid cell involved. In recent years, a more universal mechanism of immunosuppressive activity of myeloid cells has emerged: Generation of oxidized lipids. Oxidized lipids accumulate in all types of myeloid cells and are often transferred between cells. In this review, we discuss mechanisms involved in the generation and biological role of myeloid cell-derived oxidized lipids in cancer.
ISSN:0008-5472
1538-7445
DOI:10.1158/0008-5472.CAN-21-3054