Impact of Decipher Biopsy testing on clinical outcomes in localized prostate cancer in a prospective statewide collaborative

• Published in: Prostate cancer and prostatic diseases 2022-04, Vol.25 (4), p.677-683
• Main Authors: Vince, Randy A., Jiang, Ralph, Qi, Ji, Tosoian, Jeffrey J., Takele, Rebecca, Feng, Felix Y., Linsell, Susan, Johnson, Anna, Shetty, Sughand, Hurley, Patrick, Miller, David C., George, Arvin, Ghani, Khurshid, Sun, Fionna, Seymore, Mariana, Dess, Robert T., Jackson, William C., Schipper, Matthew, Spratt, Daniel E., Morgan, Todd M.
• Format: Article
• Language: English
• Subjects: 692/308; 692/53; Biomedical and Life Sciences; Biomedicine; Biopsy; Body mass; Body mass index; Body size; Cancer Research; Collaboration; Conversion; Evaluation; Failure; Gene expression; Humans; Male; Patients; Proportional Hazards Models; Prostate cancer; Prostate-Specific Antigen; Prostatectomy - adverse effects; Prostatic Neoplasms - diagnosis; Prostatic Neoplasms - epidemiology; Prostatic Neoplasms - therapy; Reproductive Medicine; Risk; Risk Factors; Statistical models; Therapy
• ISSN: 1365-7852; 1476-5608
• DOI: 10.1038/s41391-021-00428-y

Background Decipher Biopsy is a commercially available gene expression classifier used in risk stratification of newly diagnosed prostate cancer (PCa). Currently, there are no prospective data evaluating its clinical utility. We seek to assess the clinical utility of Decipher Biopsy in localized PCa patients. Methods A multi-institutional study of 855 men who underwent Decipher Biopsy testing between February 2015 and October 2019. All patients were tracked through the prospective Michigan Urological Surgery Improvement Collaborative and linked to the Decipher Genomics Resource Information Database (GRID ® ; NCT02609269). Patient matching was performed by an independent third-party (ArborMetrix Inc.) using two or more unique identifiers. Cumulative incidence curves for time to treatment (TTT) and time to failure (TTF) were constructed using Kaplan–Meier estimates. Multivariable Cox proportional hazard models were used to evaluate the independent association of high-risk Decipher scores with the conversion from AS to radical therapy and treatment failure (biochemical failure or receipt of salvage therapy). Results and limitations Eight hundred fifty-five patients underwent Decipher Biopsy testing during the study period. Of the 855 men, 264 proceeded to AS (31%), and 454 (53%) received radical therapy. In men electing AS, after adjusting for NCCN risk group, age, PSA, prostate volume, body mass index, and percent positive cores, a high-risk Decipher score was independently associated with shorter TTT (HR 2.51, 95% CI 1.52–4.13 p